Document Detail

A comparative study of two beta-blocker-diuretic combinations in the treatment of hypertension.
MedLine Citation:
PMID:  3780286     Owner:  NLM     Status:  MEDLINE    
Twenty patients with mild to severe essential hypertension completed a 12-week open crossover study to compare the effectiveness and tolerance of two beta-blocker/diuretic combinations. Patients were allocated at random to receive treatment for 6 weeks with either 40 mg propranolol plus 12.5 mg hydrochlorothiazide twice daily or 400 mg acebutolol plus 25 mg hydrochlorothiazide once daily. They were then crossed over to the alternative medication for a further 6 weeks. Blood pressures and pulse rate were monitored in the supine and erect positions at regular intervals, as were side-effects, laboratory variables and ECG. The results showed that both combinations produced significant reductions from baseline in systolic and diastolic blood pressures but that the acebutolol combination produced a significantly greater reduction in diastolic blood pressure. There was no evidence of a treatment sequence effect. The two drug treatments were reasonably well tolerated, with a trend in favour of the acebutolol combination. No clinically significant changes were observed in any of the laboratory parameters investigated and there were no ECG abnormalities.
H R Lubis; M Silalahi; Yushar
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Current medical research and opinion     Volume:  10     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-14     Completed Date:  1987-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
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MeSH Terms
Acebutolol / therapeutic use*
Drug Therapy, Combination
Hydrochlorothiazide / therapeutic use*
Hypertension / drug therapy*
Middle Aged
Propranolol / therapeutic use*
Reg. No./Substance:
37517-30-9/Acebutolol; 525-66-6/Propranolol; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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