Document Detail

A comparative study of toxic erythema of pregnancy and herpes gestationis.
MedLine Citation:
PMID:  7041949     Owner:  NLM     Status:  MEDLINE    
We compared the clinical features, histopathology, immunopathology and immunogenetics of 30 patients with toxic erythema of pregnancy and 24 patients with herpes gestationis. Although we found some clinical and histopathological overlap we highlighted several important differences. In toxic erythema of pregnancy prominent striae were frequently present. Herpes gestationis was suggested by the occurrence of periumbilical lesions, acute exacerbations immediately after delivery, and persistence of the eruption for more than 3 weeks post-partum. In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis. Toxic erythema of pregnancy did not share these immunological features. Therefore we feel that toxic erythema of pregnancy and herpes gestationis should continue to be classified as separate disorders.
R C Holmes; M M Black; J Dann; D C James; B Bhogal
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  106     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-07-19     Completed Date:  1982-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-510     Citation Subset:  IM    
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MeSH Terms
Diagnosis, Differential
Erythema / diagnosis,  immunology,  pathology*
HLA Antigens / immunology
Pemphigoid Gestationis / diagnosis,  immunology,  pathology*
Pre-Eclampsia / diagnosis
Pregnancy Complications / diagnosis,  immunology,  pathology*
Prurigo / pathology*
Skin Diseases, Vesiculobullous / pathology*
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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