Document Detail

A comparative study of three low dose progestogens, chlormadinone acetate, megestrol acetate and norethisterone, as oral contraceptives.
MedLine Citation:
PMID:  71917     Owner:  NLM     Status:  MEDLINE    
Three low dose progestogens, chlormadinone acetate (0-5 mg), megestrol acetate (0-5 mg) in oil, and norethisterone (0-35 mg), taken daily, were employed as oral contraceptives in postnatal women who desired to postpone their next pregnancy for up to a year. In a lower and middle social class population net pregnancy rates (life table) were five to six per 100 woman-years, of which about half were due to failure to take the tablets. Side effects other than menstrual disturbance were few. Norethisterone was the least likely of the three preparations to lead to discontinuation because of disturbance of menstruation. There were three ectopic gestations amongst 35 pregnancies in 4500 women-months of use. Ninety-five patients with varicose veins, 15 with a history of thrombophlebitis and 23 with a history of liver disease took progestogens without relevant untoward effects.
D F Hawkins; B Benster
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  84     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  708-13     Citation Subset:  AIM; IM    
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MeSH Terms
Chlormadinone Acetate / pharmacology*
Contraceptives, Oral*
Contraceptives, Oral, Synthetic*
Megestrol / pharmacology*
Middle Aged
Norethindrone / pharmacology*
Ovulation / drug effects
Reg. No./Substance:
0/Contraceptives, Oral; 0/Contraceptives, Oral, Synthetic; 302-22-7/Chlormadinone Acetate; 3562-63-8/Megestrol; 68-22-4/Norethindrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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