| A comparative study of the protein C system in mother's blood, cord blood and amniotic fluid. | |
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MedLine Citation:
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PMID: 20675283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activated protein C (APC) is an important anticoagulant which plays a role in pathophysiology of pregnancy, e.g. in maintenance of the uteroplacental circulation and development of the fetus as well as in pathogenesis of preeclampsia. The study objective was to compare the levels of the respective components of the protein C system (protein C, PC; protein S, PS; thrombomodulin, TM) as well as thrombin activatable fibrinolysis inhibitor - TAFI in mother's blood, cord blood and amniotic fluid. The study group consisted of 136 healthy parturients at term, divided into subgroups of 30-35. The immunoenzymatic method (ELISA) was used to measure the antigens of the components studied. The concentrations of PC and PS antigens were the highest in the mother's blood plasma (135.11+/-1.05% and 92.0+/-13.24%, respectively), lower in cord blood plasma (57.60+/-10.32% and 33.19+/-4.96%, respectively) and the lowest in amniotic fluid (6.75+/-3.50% and 2.40+/-1.64%, respectively); the differences between the levels of that of mother, fetus and amniotic fluid were statistically significant (p< or =0.0001). The TM and TAFI antigen concentrations were the highest in cord blood plasma (11.35+/-3.71 ng/ml and 91.50 (median; range: 71.76-160.77) ng/ml, respectively) and lower in maternal plasma (4.51+/-0.71 ng/ml and 55.46 - median; range: 39.77-68.54 ng/ml, respectively); the differences between the levels of that of cord blood plasma and maternal plasma were statistically significant (p< or =0.0001). Of the three protein C system components, PC and PS occur in relatively high concentrations in maternal blood, being lower in fetal blood and the lowest in amniotic fluid. On the other hand, as an exception, the concentrations of TM and TAFI are the highest in fetus blood. |
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Authors:
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Mieczysław Uszyński; Waldemar Uszyński; Ewa Zekanowska; Jarosław Kuczyński; Marek Szymański |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society Volume: 48 ISSN: 1897-5631 ISO Abbreviation: Folia Histochem. Cytobiol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502651 Medline TA: Folia Histochem Cytobiol Country: Poland |
Other Details:
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Languages: eng Pagination: 262-6 Citation Subset: IM |
Affiliation:
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Department of Propedeutics of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland. kizproped@cm.umk.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / metabolism* Enzyme-Linked Immunosorbent Assay Female Fetal Blood / metabolism* Humans Labor, Obstetric / blood Pregnancy / blood* Protein C / metabolism* Protein S / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Protein C; 0/Protein S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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