Document Detail


A comparative study on prophylactic irradiation to the whole neck and to the upper neck for neck lymph node-negative nasopharyngeal carcinoma patients.
MedLine Citation:
PMID:  23606573     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: To investigate the prophylactic irradiation volume to neck drainage areas for N0 classification nasopharyngeal carcinoma(NPC) patients treated by intensity-modulated radiotherapy(IMRT). Methods: From January 2003 to October 2008,270 N0 classification (AJCC 2002 staging system) NPC patients who had undergone IMRT were retrospectively analyzed. Among all the patients, 171 patients received prophylactic upper-neck irradiation, and 99 patients received prophylactic whole-neck irradiation. Results: At a median follow-up of 65.1 months(range,4-106 months). The 5-year overall survival(OS), nodal recurrence-free survival(NRFS) and distant metastasis-free survival (DMFS) rates of the upper neck group and the whole neck group were 93.6% vs 90.9%(P=0.553), 99.4% vs 99.0%(P=0.278), 98.8% vs 94.9%(P=0.128). A total of three neck recurrences were found, including two from the whole neck group and one from the upper neck group. The latter (0.6%)was out-of-field recurrence. Conclusions: Prophylactic irradiation to the upper neck(level II,III,VA) may be feasible for neck lymph node-negative NPC patients. Head Neck, 2013.
Authors:
Lei Zeng; Xue-Ming Sun; Chun-Yan Chen; Fei Han; Ying Huang; Wei-Wei Xiao; Shuai Liu; Yun-Ming Tian; Xiao-Wu Deng; Tai-Xiang Lu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-22
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.
Affiliation:
State Key Laboratory Oncology in Southern China, Guangzhou, PR China; Department of Radiation Oncology, Cancer Center of Sun Yat-Sen University, Guangzhou, PR China.
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