Document Detail

A comparative study of progesterone synthesis by term human fetal amnion and chorion.
MedLine Citation:
PMID:  8606343     Owner:  NLM     Status:  MEDLINE    
Activity of 3 beta-hydroxysteroid dehydrogenase-5, 4-en isomerase was investigated with [7n-3H] pregnenolone as substrate in the homogenates of amnion and chorion collected from women (n = 6, age 20-34 years) after spontaneous labour at term (37-40 weeks gestation) from uncomplicated pregnancies. Controls were heat-denatured homogenates instead of fresh homogenates. Reverse-isotope dilution analysis gave positive identification of [3H] progesterone in all incubations of viable tissues. This metabolite was not evident in the controls. The extent of enzymic conversion of chorion, 1.4-31.1% was consistently higher than that of the amnion, 0.66-1.7%. The results show that the human fetal membranes can be a source of progesterone during pregnancy. The metabolic capability may have physiological significance in the induction and progression of labour to parturition.
R Gunasegaram; K L Peh; A Loganath; W P Chow; P C Chew; S Shanmugaratnam
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  23     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1995  
Date Detail:
Created Date:  1996-05-17     Completed Date:  1996-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  371-7     Citation Subset:  IM    
University Department of Obstetrics and Gynecology, National University Hospital, Singapore.
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MeSH Terms
Amnion / metabolism*
Chorion / metabolism*
Pregnenolone / metabolism
Progesterone / biosynthesis*
Reg. No./Substance:
10028-17-8/Tritium; 145-13-1/Pregnenolone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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