Document Detail


A comparative study of primary and secondary hemifacial spasm.
MedLine Citation:
PMID:  16533973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hemifacial spasm (HFS) is a common movement disorder. OBJECTIVE: To evaluate possible differences in the demographic and clinical features between primary and secondary HFS. DESIGN: In-person interview using a standardized questionnaire to collect demographic and clinical data. SETTING: A multicenter study that included patients with HFS attending 3 Italian academic centers. Patients Two hundred fourteen patients with HFS. MAIN OUTCOME MEASURE: A complete neurological examination assessed the current muscle distribution of spasm and the presence of synkinetic movements between upper and lower facial muscles. RESULTS: The study sample comprised 214 patients with HFS, 81 men and 133 women, having a mean +/- SD age of 65.9 +/- 12.3 years; 164 patients were classified as having primary HFS and 50 patients (48 postparalytic and 2 symptomatic cases) were classified as having secondary HFS. Patients with primary and those with secondary HFS had similar mean +/- SD ages at onset (54.9 +/- 13.5 vs 57.0 +/- 12.8 years), male-female ratios (63:101 vs 18:32), right-sided-left-sided HFS (77:86 [1 bilateral] vs 21:28 [1 bilateral]), and frequencies of familial cases (2.9% vs 2.0%), respectively. Most patients (65.0%) with primary HFS had initial symptoms of periocular muscle contractions alone and had subsequent involvement of the lower facial muscles. Most patients (72.0%) with secondary HFS reported initial involvement of the upper and lower facial muscles simultaneously. Signs of synkinesis were present in primary (43.3%) and secondary (58.0%) HFS. CONCLUSIONS: Patients with primary and those with secondary HFS share common demographic and clinical features, including sex distribution, age at onset, affected side of HFS, synkinesis, and rarity of familial cases. Signs of synkinesis were present in significant proportions of patients with primary or secondary HFS. The 2 forms differed in clinical presentation.
Authors:
Carlo Colosimo; Matteo Bologna; Simona Lamberti; Laura Avanzino; Lucio Avanzino; Lucio Marinelli; Laura Marinelli; Giovanni Fabbrini; Giovanni Abbruzzese; Giovanni Defazio; Alfredo Berardelli
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Multicenter Study    
Journal Detail:
Title:  Archives of neurology     Volume:  63     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-04-25     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Chi-Square Distribution
Demography*
Female
Hemifacial Spasm* / classification,  epidemiology,  physiopathology
Humans
Interviews as Topic / methods
Italy / epidemiology
Male
Middle Aged
Neurologic Examination
Questionnaires
Comments/Corrections
Comment In:
Arch Neurol. 2006 Aug;63(8):1204; author reply 1204   [PMID:  16908755 ]
Erratum In:
Arch Neurol. 2006 Sep;63(9):1241
Note: Avanzino, Lucio [corrected to Avanzino, Laura]; Marinelli, Laura [corrected to Marinelli, Lucio]

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