Document Detail

A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis.
MedLine Citation:
PMID:  22529484     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: To compare the cure rates of oral single dose of metronidazole (2 g), tinidazole (2 g), secnidazole (2 g), and ornidazole (1.5 g) in cases of bacterial vaginosis.
MATERIALS AND METHODS: This was a prospective, comparative, randomized clinical trial on 344 Indian women (86 women in each group) who attended a gynecology outpatient department with complaint of abnormal vaginal discharge or who had abnormal vaginal discharge on Gynecological examination but they did not complaint of it. For diagnosis and cure rate of bacterial vaginosis, Amsel's criteria were used. Statistical analysis was done by Chi-square test of proportions. The cure rate was compared considering metronidazole cure rate as gold standard.
RESULTS: At 1 week, the cure rate of tinidazole and ornidazole was 100% and at 4 weeks, it was 97.7% for both drugs (P<0.001). Secnidazole had cure rate of 80.2% at 4 weeks (P=NS). Metronidazole showed a cure rate of 77.9% at 4 weeks, which is the lowest of all four drugs.
CONCLUSION: Tinidazole and ornidazole have better cure rate as compared to metronidazole in cases of bacterial vaginosis.
Jyoti Thulkar; Alka Kriplani; Nutan Agarwal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmacology     Volume:  44     ISSN:  1998-3751     ISO Abbreviation:  Indian J Pharmacol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-09-10     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7902477     Medline TA:  Indian J Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  243-5     Citation Subset:  -    
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
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