Document Detail


A comparative study of markers of inflammation for the assessment of cardiovascular risk in patients presenting to the emergency department with acute chest pain suggestive of acute coronary syndrome.
MedLine Citation:
PMID:  16046018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The role of inflammation in the pathogenesis of acute coronary syndrome (ACS) is established. Little is known however, regarding the use of inflammatory markers as predictors of future cardiovascular events in patients presenting to the emergency department (ED) with suspected ACS. HYPOTHESIS: To assess whether biomarkers that predict cardiovascular risk in apparently healthy individuals and coronary artery disease patients are useful predictors of future cardiovascular events in patients presenting to the ED with chest pain suggestive of ACS. METHODS: We compared the abilities of serum C-reactive protein (hs-CRP), albumin and leukocyte count to identify subjects with ACS and those who are at high risk of developing events during a 30-day follow-up. RESULTS: 144 patients (mean age 62+/-13 years, 45 female) presenting to the ED <3 h after the onset of symptoms suggestive of ACS were evaluated. Final hospital diagnoses were non-ischemic chest pain in 43 (30%) and ACS in 101 (70%) patients. Patients with ACS had significantly higher leukocyte count (p<0.0001) and hs-CRP levels (p<0.02) and lower albumin concentrations, compared to patients with NICP (p<0.0001). Lower albumin concentrations (p=0.03) and hs-CRP (p=0.049) were predictors of recurrent events at 30 days. On multivariate analysis, however, only leukocyte count was a predictor of ACS (OR 20.9; 95% CI: 3.7-19.5; p=0.01) and high hs-CRP levels were a predictor of clinical outcome (OR 2.8; 95% CI: 1.5-5.2; p=0.001). CONCLUSIONS: Leukocyte count is an independent predictor of ACS in patients presenting to the ED with chest pain suggestive of ACS and high hs-CRP levels are an independent predictor of clinical outcome in ACS patients.
Authors:
Debashis Roy; Juan Quiles; Pablo Avanzas; Ramón Arroyo-Espliguero; Manas Sinha; Juan Carlos Kaski
Related Documents :
17489768 - A comparation of coronary artery bypass grafting with and without cardiopulmonary bypas...
17654318 - Underuse of american college of cardiology/american heart association guidelines in hem...
18928168 - Cardiovascular risk with score system in patients with different degree of renal functi...
12407648 - Ace inhibitors and survival of hemodialysis patients.
7426428 - The potassium iodide patch test in the dermatitis herpetiformis in relation to treatmen...
10836368 - Relation between steroid dose, body composition and physical activity in renal transpla...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2005-07-20
Journal Detail:
Title:  International journal of cardiology     Volume:  109     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-15     Completed Date:  2006-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  317-21     Citation Subset:  IM    
Affiliation:
Coronary Artery Disease Research Unit, St George's Hospital Medical School, London, United Kingdom.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Biological Markers
C-Reactive Protein / analysis*
Chest Pain / blood*
Coronary Disease / etiology*
Electrocardiography
Emergency Medical Services
Female
Humans
Inflammation / complications*
Leukocyte Count*
Male
Middle Aged
Serum Albumin / analysis*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prognostic value of resting end-tidal carbon dioxide in patients with heart failure.
Next Document:  The value of genetic information in selecting dairy replacements.