| A comparative study of contrast agents for endoscopic retrograde pancreatography. | |
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MedLine Citation:
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PMID: 1928034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pancreatitis is a major cause of morbidity and mortality secondary to endoscopic retrograde pancreatography (ERP). One factor that may cause post-ERP pancreatitis is the type of contrast media utilized during the procedure. The purpose of this prospective, double-blind, randomized study was to evaluate the effects of three contrast agents of differing osmolality and ionicity on changes between pre- and post-ERP chemical changes in serum amylase and lipase and development of clinical symptoms of acute pancreatitis. Our study of 53 patients showed that those who received Omnipaque a non-ionic, relatively iso-osmolar contrast agent, had a significantly lower serum amylase (p = 0.0038) and serum lipase (p = 0.0002) in post-ERP serological markers, compared with patients who received the ionic agents, Hypaque meglumine 60% or Hexabrix. In addition, the development of clinical symptoms of pancreatitis was less in patients who received Omnipaque than in those who received Hexabrix or Hypaque (1 vs. 3 vs. 4). No significant difference was found between patients who received ionic agents. No patient who received Omnipaque needed hospitalization, whereas one (6%) patient who received Hexabrix was hospitalized compared to three (20%) hospitalized patients who received Hypaque. When the initial cost and cost of hospitalization were compared, the non-ionic contrast medium was also found to be more cost-effective for the patient. In summary, the risk of post-ERP acute pancreatitis was significantly lower for patients who received the non-ionic contrast agent than for those who received the ionic agents. |
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Authors:
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J S Barkin; G L Casal; D K Reiner; R I Goldberg; R S Phillips; S Kaplan |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 86 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1991-10-28 Completed Date: 1991-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1437-41 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of Miami, School of Medicine/Mt. Sinai Medical Center, Florida. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cholangiopancreatography, Endoscopic Retrograde / adverse effects, methods* Diatrizoate Meglumine / diagnostic use* Double-Blind Method Female Humans Iohexol / diagnostic use* Ioxaglic Acid / diagnostic use* Male Middle Aged Osmolar Concentration Pancreatitis / etiology |
| Chemical | |
Reg. No./Substance:
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131-49-7/Diatrizoate Meglumine; 59017-64-0/Ioxaglic Acid; 66108-95-0/Iohexol |
| Comments/Corrections | |
Comment In:
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Am J Gastroenterol. 1992 May;87(5):682-3; author reply 684-5
[PMID:
1595669
]
Am J Gastroenterol. 1992 May;87(5):683-4; author reply 684-5 [PMID: 1595671 ] Am J Gastroenterol. 1992 May;87(5):683; author reply 684-5 [PMID: 1595670 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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