Document Detail

A comparative study of colloidal bismuth subcitrate and cimetidine on the healing and recurrence of duodenal ulcer.
MedLine Citation:
PMID:  6761849     Owner:  NLM     Status:  MEDLINE    
In a randomised open study of 28 outpatients with endoscopically proven duodenal ulcers, 14 patients were treated with colloidal bismuth subcitrate (CBS) and 14 patients with cimetidine tablets. Clinical and endoscopic assessments were made before starting therapy and then four and six weeks after the commencement of therapy. The trial was carried out in adult patients and included 21 men and 7 women. After four weeks treatment, 9 of the CBS-treated ulcers (64%) and 8 of the cimetidine treated ulcers (57%) were completely healed. After 6 weeks of therapy, complete ulcer healing was seen in 86% of ulcers in each group. In both groups the reduction of the pain scores after 4 and 6 weeks was highly significant. No adverse reactions were observed in respect of blood pressure or the various laboratory data. The blood bismuth levels after four and six weeks treatment with CBS remained within the safety limits. To determine the ulcer relapse rate, 20 of the 24 completely healed ulcer patients (10 of each group) were followed-up for a period of three months. Endoscopic control showed that recurrent ulcer was found in one CBS-treated patient and in three cimetidine-treated patients. The results showed that CBS tablets are as effective as cimetidine in the treatment of duodenal ulcer. Our results confirm the previously reported CBS efficacy in duodenal ulcer after using the liquid preparation.
G Vantrappen; P Schuurmans; P Rutgeerts; J Janssens
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of gastroenterology. Supplement     Volume:  80     ISSN:  0085-5928     ISO Abbreviation:  Scand. J. Gastroenterol. Suppl.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2008-02-13    
Medline Journal Info:
Nlm Unique ID:  0437034     Medline TA:  Scand J Gastroenterol Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Bismuth / therapeutic use*
Cimetidine / therapeutic use*
Clinical Trials as Topic
Duodenal Ulcer / drug therapy*,  pathology
Follow-Up Studies
Guanidines / therapeutic use*
Middle Aged
Organometallic Compounds*
Time Factors
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Guanidines; 0/Organometallic Compounds; 51481-61-9/Cimetidine; 57644-54-9/bismuth tripotassium dicitrate; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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