| A comparative study of clarithromycin and penicillin VK in the treatment of outpatients with streptococcal pharyngitis. | |
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MedLine Citation:
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PMID: 1827105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This double-blind, randomized 17-centre clinical trial compared the safety and efficacy of clarithromycin (2 x 125 mg capsules) 12-hourly and penicillin VK (2 x 125 mg tablets in capsules) 6-hourly in the treatment of proven Group A, beta-haemolytic streptococcal pharyngitis. One hundred and twenty-eight patients (clarithromycin: 65, penicillin VK: 63) were enrolled in the study and included in the safety analysis. Clinical and bacteriological evaluations were performed on treatment days 5-7, and within two to ten and 15 to 56 days post-treatment. The post-treatment clinical success and bacteriological cure rates for clarithromycin were 95% (41/43) and 88% (38/43), respectively, with both rates 91% (43/47) for penicillin VK. Three clarithromycin patients withdrew because of adverse events, but only one of these events was possibly drug related. More clarithromycin patients (19/65) reported digestive system related adverse events than did penicillin VK patients (8/63); however, there was no significant difference between treatment groups in the overall number of patients reporting adverse events. Clarithromycin (250 mg, 12-hourly) is a safe and effective as penicillin VK (250 mg, 6-hourly) in the treatment of streptococcal pharyngitis. |
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Authors:
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R T Bachand |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 27 Suppl A ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-06-04 Completed Date: 1991-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 75-82 Citation Subset: IM |
Affiliation:
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Abbott International Ltd, Abbott Park, Illinois 60064-3500. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ambulatory Care Child Clarithromycin Double-Blind Method Erythromycin / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Female Humans Male Middle Aged Penicillin V / administration & dosage, adverse effects, therapeutic use* Pharyngitis / drug therapy* Streptococcal Infections / drug therapy* Streptococcus pyogenes* |
| Chemical | |
Reg. No./Substance:
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114-07-8/Erythromycin; 81103-11-9/Clarithromycin; 87-08-1/Penicillin V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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