Document Detail


A comparative study of the biological properties of Australian elapid venoms.
MedLine Citation:
PMID:  1981349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The hemorrhagic, procoagulant, anticoagulant, protease, phosphodiesterase, alkaline phosphomonoesterase, L-amino acid oxidase, acetylcholinesterase, arginine ester hydrolase, phospholipase A, 5'-nucleotidase and hyaluronidase activities of 39 samples of venoms from 13 species (15 taxa) of Australian elapids were determined and the Sephadex G-75 gel filtration patterns for some of the venoms were also examined. 2. The results indicate that Australian elapid venoms can be divided into two groups: procoagulant Australian venoms (including N. scutatus, N. ater, O. scutellatus, O. microlepidotus, P. porphyriacus, T. carinatus, H. stephensii and P. textilis) and non-procoagulant Australian venoms (including A. superbus, P. colletti, P. australis, P. guttatus and A. antarcticus). 3. The non-procoagulant Australian venoms exhibited biological properties similar to other elapid venoms, while the procoagulant Australian venoms exhibited some properties characteristic of viperid venoms. 4. The data show that information on venom biological properties can be used for differentiation of many species of Australian elapids. 5. Particularly useful for this purpose are the hyaluronidase, alkaline phosphomonoesterase, acetylcholinesterase, and the procoagulant activities and the Sephadex G-75 gel filtration patterns of the venoms.
Authors:
N H Tan; G Ponnudurai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology     Volume:  97     ISSN:  0742-8413     ISO Abbreviation:  Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-09     Completed Date:  1991-04-09     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8310013     Medline TA:  Comp Biochem Physiol C     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-106     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Malaya, Kuala Lumpur.
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MeSH Terms
Descriptor/Qualifier:
Animals
Australia
Chromatography, Gel
Elapid Venoms / isolation & purification,  metabolism,  pharmacology,  toxicity*
Hydrolases / isolation & purification,  metabolism
Snakes
Species Specificity
Chemical
Reg. No./Substance:
0/Elapid Venoms; EC 3.-/Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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