| A comparative study of the arterial tissue metabolism in atherosensitive and atheroresistant species. I. Comparison between rabbit and rat aortas. | |
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MedLine Citation:
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PMID: 7347389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty eight enzymatic activities and four macromolecular substances have been histochemically compared in rat and rabbit aortas, embedded in a common block. The study was carried out at different stages of development: 3 days, 3 months, 7-9 months and 17-19 months. In addition, lipase and cholinesterase were biochemically assayed in adult rat and rabbit aortas. The rat aortas (atheroresistant) had a better supply of aerobic oxidoreductases [linked to the pentose pathway (G6PD, 6PGD) as well as to the Krebs cycle (SD, ICD)], lipolytic enzymes (acid esterases, cholinesterase, lipase), lysosomal enzymes (acid PH/ase, Aryl-sulf/ase - Betaglu/ase), ADPase - ATPase - AlK Ph/ase Alpha GPD and acid lipids. Rabbit aortas (atherosensitive) were richer in metachromatic GAG, UDPGD (GAG Anabolism), glycogen, and related enzymes (phosphorylase, glycogen synthetase) as well as 5'-nucleotidase, Beta HBD, Lactate D and Aldolase. These differences support the hypothesis that arterial atherosensitivity is related to the activity and efficiency of smooth muscle cell energetic and catabolic processes, which govern the behaviour of lipids, proteins and carbohydrates as they penetrate the arterial wall. The factors that determine the proliferative and sclerogenic responses of arterial tissues to aggressions and, in particular, the response to lipids, remain, however, to be determined. |
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Authors:
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P Hadjiisky; J Renais; L Scebat |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Paroi artérielle Volume: 7 ISSN: 0398-7655 ISO Abbreviation: Paroi Arterielle Publication Date: 1981 |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606268 Medline TA: Paroi Arterielle Country: FRANCE |
Other Details:
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Languages: eng Pagination: 155-65 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Aorta, Thoracic / enzymology*, physiopathology Cholinesterases / metabolism Glucosephosphates / metabolism Glycosaminoglycans / metabolism Lipidoses / enzymology*, physiopathology Lysosomes / enzymology Male Oxidoreductases / metabolism Phosphogluconate Dehydrogenase / metabolism Rabbits Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Glucosephosphates; 0/Glycosaminoglycans; EC 1.-/Oxidoreductases; EC 1.1.1.43/Phosphogluconate Dehydrogenase; EC 3.1.1.8/Cholinesterases |
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