| A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits. | |
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MedLine Citation:
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PMID: 21959808 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C. |
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Authors:
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Nawazish-I-Husain Syed; Shamas Arshad; Amir Ali Rizvi Syed; Maqsood Ahmad; Farrakh Zia Khan; Bashir Ahmad |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 24 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 479-84 Citation Subset: IM |
Affiliation:
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University College of Pharmacy, University of the Punjab, Lahore, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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