Document Detail

A comparative study of allogenic "first set" and "second set" skin rejection in mice.
MedLine Citation:
PMID:  127938     Owner:  NLM     Status:  MEDLINE    
In our case, where the difference between donor WHT/Ht(H--2d) and recipient C57B1/6 (H--2b) was at the H--2 locus of histocompatibility, the FSg rejection occurred between the 6th and the 10th day, while the SSg rejection was two days earlier. The morphological study emphasized that the cellular infiltrate in the FSg is predominantly lymphocytic, while in the SSg it is predominantly granulocytic. The vascularization settles on the second day postgrafting in the FSg as well as in the SSg, but is scarce and quickly destroyed in the SSg, thus being explained the scanty supply of lymphocytes in the latter graft type. The histochemical reactions demonstrated an increase of the NMPS in skin allograft from the moment of settling till the end of the rejection and a decrease of AMPS, till the complete disappearance, in the rejected graft. Little morphological differences were found between colateral draining nodes and contralateral ones during the reaction to the graft. An important feature described is the presence at the bed graft level of some cells morphologically identical to the IB encountered in great number in the TDA of lymph nodes in the allograft-bearing mice.
M Nedelea; S Dima; G Sandru; V Nicolaescu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Morphologie et embryologie     Volume:  21     ISSN:  0377-5038     ISO Abbreviation:  Morphol Embryol (Bucur)     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-26     Completed Date:  1976-02-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7512183     Medline TA:  Morphol Embryol (Bucur)     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  53-7     Citation Subset:  IM    
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MeSH Terms
Glycosaminoglycans / metabolism
Graft Rejection*
Lymph Nodes / pathology
Skin / metabolism
Skin Transplantation*
Transplantation, Homologous
Reg. No./Substance:

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