Document Detail

A comparative study of oxytocin/misoprostol/methylergometrine for active management of the third stage of labor.
MedLine Citation:
PMID:  24966500     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVES: To study oxytocin, misoprostol, and methylergometrine in active management of the third stage of labor and determine duration of the third stage of labor, blood loss, adverse effects, and need for additional uterotonics in each group.
METHODS: Clinical trial of 300 women with healthy singleton pregnancy allocated into three groups to receive either: 10 IU intravenous oxytocin infusion, 600 μg sublingual misoprostol, or 200 μg intravenous methylergometrine. Primary outcome measure was blood loss in the third stage of labor; secondary measures were duration of the third stage, side effects, and complications.
RESULTS: Subjects who received 600 μg of misoprostol had the least blood loss, followed by oxytocin, and methylergometrine. The shortest mean duration of the third stage was with misoprostol. Shivering and pyrexia were observed in misoprostol group, and raised blood pressure in methylergometrine group.
CONCLUSIONS: Misoprostol is as effective as oxytocin and both are more effective than methylergometrine in active management of the third stage of labor.
Megha Sharma; Parneet Kaur; Khushpreet Kaur; Arvinder Kaur; Preet Kanwal Kaur; Mohi Manjit Kaur
Publication Detail:
Type:  Journal Article     Date:  2014-03-12
Journal Detail:
Title:  Journal of obstetrics and gynaecology of India     Volume:  64     ISSN:  0971-9202     ISO Abbreviation:  J Obstet Gynaecol India     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-06-26     Completed Date:  2014-06-26     Revised Date:  2014-06-30    
Medline Journal Info:
Nlm Unique ID:  0374763     Medline TA:  J Obstet Gynaecol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  -    
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