Document Detail

A comparative study of Japanese and British BCG vaccine strains in newborn infants.
MedLine Citation:
PMID:  2655676     Owner:  NLM     Status:  MEDLINE    
A prospective study on the British and Japanese BCG vaccines in newborn infants was carried out in which 317 and 285 infants were randomly allocated and vaccinated with the British and Japanese BCG vaccines, respectively. Four follow-up examinations were carried out with an average of 98% of the study cohort attending all sessions. About half the infants did not produce any visible response at the end of the first week. All, by the end of the third month, had characteristic BCG scars with an average diameter of 4.6 mm. A Mantoux test was carried out at six months. A mean skin induration of 7.2 mm (SD 5.3 mm) was recorded. Significantly higher proportions of infants given Japanese BCG were found to be tuberculin convertors (74.7%) when compared to those given British BCG (51.4%). Breast-feeding practices and the mothers' tuberculin status did not influence markedly their infants response to tuberculin.
T E Goh; M Low; C H Chen; T H Tan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Asia-Pacific journal of public health / Asia-Pacific Academic Consortium for Public Health     Volume:  3     ISSN:  1010-5395     ISO Abbreviation:  Asia Pac J Public Health     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-12     Completed Date:  1989-07-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8708538     Medline TA:  Asia Pac J Public Health     Country:  HONG KONG    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
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MeSH Terms
BCG Vaccine*
Child, Preschool
Clinical Trials as Topic
Double-Blind Method
Great Britain
Infant, Newborn
Prospective Studies
Random Allocation
Tuberculin Test
Tuberculosis / immunology,  prevention & control*
Reg. No./Substance:
0/BCG Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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