| The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis. | |
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MedLine Citation:
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PMID: 19777373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Comparative evidence regarding the responsiveness of the EQ-5D and SF-6D in arthritis patients is conflicting and insufficient across the range of disease severity. We examined the comparative responsiveness of the EQ-5D and SF-6D in cohorts of patients with early inflammatory disease through to severe rheumatoid arthritis (RA). METHODS: Responsiveness was tested using the effect size (ES) and standardised response mean (SRM). Correlation of change in EQ-5D and SF-6D with disease specific measures was tested using Pearson correlations and the Steiger's Z test. Treatment response and self-reported change were used as anchors of important change. RESULTS: The EQ-5D was more responsive to deterioration (ES ratio (EQ-5D/SF-6D): 1.6-3.0) and the SF-6D more responsive to improvement (ES ratio (SF-6D/EQ-5D): 1.1-1.8) in health. The SF-6D did not respond well to deterioration in patients with established severe RA (ES and SRM 0.08). The EQ-5D provided larger absolute mean change estimates but with greater variance compared to the SF-6D. CONCLUSIONS: The comparative responsiveness of the EQ-5D and SF-6D differs according to the direction of change. The level of mean change of the EQ-5D relative to the SF-6D has implications for cost-effectiveness analysis. Use of the SF-6D in patients with severe progressive disease may be inappropriate. |
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Authors:
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M J Harrison; L M Davies; N J Bansback; M J McCoy; S M M Verstappen; K Watson; D P M Symmons; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-24 |
Journal Detail:
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Title: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation Volume: 18 ISSN: 1573-2649 ISO Abbreviation: Qual Life Res Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-13 Revised Date: 2011-12-01 |
Medline Journal Info:
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Nlm Unique ID: 9210257 Medline TA: Qual Life Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1195-205 Citation Subset: IM |
Affiliation:
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ARC Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK. mark.harrison@manchester.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / physiopathology, psychology* Female Humans Male Middle Aged Outcome Assessment (Health Care) Quality of Life* Questionnaires* Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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17552//Arthritis Research UK; //Arthritis Research UK |
| Investigator | |
Investigator/Affiliation:
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Allister Taggart / ; Tom Price / ; Neil Hopkinson / ; Sheila O'Reilly / ; George Kitas / ; Duncan Porter / ; Hilary Capell / ; Paul Emery / ; Ernest Choy / ; Deborah Symmons / ; Ian Bruce / ; Ian Griffiths / ; David Scott / ; Paul Thompson / ; Fiona McCrae / ; Romela Benitha / ; Ronald Jubb / ; Rikki Abernethy / ; Andy Hassell / ; David Walsh / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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