Document Detail

The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis.
MedLine Citation:
PMID:  19777373     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Comparative evidence regarding the responsiveness of the EQ-5D and SF-6D in arthritis patients is conflicting and insufficient across the range of disease severity. We examined the comparative responsiveness of the EQ-5D and SF-6D in cohorts of patients with early inflammatory disease through to severe rheumatoid arthritis (RA).
METHODS: Responsiveness was tested using the effect size (ES) and standardised response mean (SRM). Correlation of change in EQ-5D and SF-6D with disease specific measures was tested using Pearson correlations and the Steiger's Z test. Treatment response and self-reported change were used as anchors of important change.
RESULTS: The EQ-5D was more responsive to deterioration (ES ratio (EQ-5D/SF-6D): 1.6-3.0) and the SF-6D more responsive to improvement (ES ratio (SF-6D/EQ-5D): 1.1-1.8) in health. The SF-6D did not respond well to deterioration in patients with established severe RA (ES and SRM 0.08). The EQ-5D provided larger absolute mean change estimates but with greater variance compared to the SF-6D.
CONCLUSIONS: The comparative responsiveness of the EQ-5D and SF-6D differs according to the direction of change. The level of mean change of the EQ-5D relative to the SF-6D has implications for cost-effectiveness analysis. Use of the SF-6D in patients with severe progressive disease may be inappropriate.
M J Harrison; L M Davies; N J Bansback; M J McCoy; S M M Verstappen; K Watson; D P M Symmons;
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-24
Journal Detail:
Title:  Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation     Volume:  18     ISSN:  1573-2649     ISO Abbreviation:  Qual Life Res     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-13     Revised Date:  2011-12-01    
Medline Journal Info:
Nlm Unique ID:  9210257     Medline TA:  Qual Life Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1195-205     Citation Subset:  IM    
ARC Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
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MeSH Terms
Arthritis, Rheumatoid / physiopathology,  psychology*
Middle Aged
Outcome Assessment (Health Care)
Quality of Life*
Reproducibility of Results
Grant Support
17552//Arthritis Research UK; //Arthritis Research UK
Allister Taggart / ; Tom Price / ; Neil Hopkinson / ; Sheila O'Reilly / ; George Kitas / ; Duncan Porter / ; Hilary Capell / ; Paul Emery / ; Ernest Choy / ; Deborah Symmons / ; Ian Bruce / ; Ian Griffiths / ; David Scott / ; Paul Thompson / ; Fiona McCrae / ; Romela Benitha / ; Ronald Jubb / ; Rikki Abernethy / ; Andy Hassell / ; David Walsh /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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