| A comparative prospective study of conventional regimen with chronic low-dose administration of follicle-stimulating hormone for anovulation associated with polycystic ovary syndrome. | |
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MedLine Citation:
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PMID: 7890055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare efficiency of conventional and chronic low-dose regimens for treatment of anovulation associated with polycystic ovary syndrome (PCOS). DESIGN: Fifty participants divided into two equal groups. The first group was treated with urinary human FSH using a conventional stepwise protocol and the second group was treated with a regimen of chronic low-dose and small incremental rises with urinary human FSH or with recombinant human FSH for a maximum of three cycles. SETTING: Tertiary referral university hospital fertility unit. PATIENTS: Fifty infertile women with clomiphene citrate-resistant anovulation associated with PCOS. MAIN OUTCOME MEASURES: Pattern of follicular development, amount of FSH required, serum E2 concentrations, cycle fecundity, cumulative conception, and live birth rates. Multiple pregnancy and ovarian hyperstimulation syndrome (OHSS) rates. RESULTS: Compared with the conventional dose protocol, the chronic low-dose regimen yielded slightly improved pregnancy rates (40% versus 24%) while completely avoiding OHSS and multiple pregnancies, which were prevalent (11% and 33%, respectively) with conventional therapy. Monofollicular development was induced in 74% versus 27% of cycles, and the total number of follicles > 16 mm and E2 concentrations were half those observed on conventional therapy. CONCLUSIONS: For women with PCOS, a chronic low-dose regimen of FSH eliminated complications of OHSS and multiple pregnancies while maintaining a satisfactory pregnancy rate. This modality, thus, has distinct advantages and could well replace conventional gonadotropin therapy for these patients. |
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Authors:
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R Homburg; T Levy; Z Ben-Rafael |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 63 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-04-17 Completed Date: 1995-04-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 729-33 Citation Subset: IM |
Affiliation:
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Fertility Unit, Golda Meir Medical Center, Petah Tiqva, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anovulation / drug therapy*, etiology* Clomiphene / therapeutic use Dose-Response Relationship, Drug Drug Resistance Female Follicle Stimulating Hormone / administration & dosage*, adverse effects, therapeutic use Humans Ovarian Hyperstimulation Syndrome / chemically induced Ovulation Induction / methods Polycystic Ovary Syndrome / complications* Pregnancy Pregnancy, Multiple Prospective Studies Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 9002-68-0/Follicle Stimulating Hormone; 911-45-5/Clomiphene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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