Document Detail


A comparative multicentre trial of halometasone/triclosan cream and betamethasone dipropionate/gentamicin sulphate cream in the treatment of infected acute eczematous dermatitis.
MedLine Citation:
PMID:  6339292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A multicentre, between-patient, comparative trial was carried out to compare the efficacy and tolerability of a cream containing 0.05 halometasone and 1% triclosan with those of a cream with 0.05% betametasone dipropionate and 0.1% gentamicin sulphate in patients suffering from infected acute ezcematous dermatoses. In the evaluable trial population, consisting of 265 patients, halometasone/triclosan cream yielded a significantly (p = 0.001) higher success rate ('good' to 'very good' results), namely 96%, than the comparative cream (80%). Halometasone/triclosan cream also displayed a significantly (p = 0.008) higher cure rate (73.9%) than that observed with the comparative preparation (58.6%). The proportion of patients obtaining an early cure, i.e. in less than 20 days, was significantly (p = 0.0005) higher with halometasone/triclosan cream (42.5%) than with the comparative preparation (22.6%). The two preparations did not differ significantly with regard to the incidence and severity of adverse effects.
Authors:
H Weitgasser; C Schindléry; V Macarol
Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  11 Suppl 1     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1983  
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Administration, Topical
Adolescent
Adult
Aged
Anti-Inflammatory Agents / administration & dosage*,  adverse effects
Betamethasone / administration & dosage,  analogs & derivatives*
Clinical Trials as Topic
Drug Combinations
Eczema / drug therapy*
Female
Gentamicins / administration & dosage*
Humans
Male
Middle Aged
Phenyl Ethers / administration & dosage*
Triclosan / administration & dosage*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Drug Combinations; 0/Gentamicins; 0/Phenyl Ethers; 3380-34-5/Triclosan; 378-44-9/Betamethasone; 50629-82-8/halometasone; 5593-20-4/betamethasone-17,21-dipropionate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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