Document Detail


The comparative effects of sevoflurane vs. isoflurane on cerebrovascular carbon dioxide reactivity in patients with hypertension.
MedLine Citation:
PMID:  17714576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Sevoflurane has been shown to have different effects on cerebrovascular CO(2) reactivity in comparison with isoflurane. In this study, the comparative effects of sevoflurane vs. isoflurane on cerebrovascular CO(2) reactivity were examined in patients with hypertension. METHODS: Fifty patients, 30 hypertensive and 20 normotensive, were included in this study. The 30 hypertensive patients were divided into two groups: sevoflurane and isoflurane. Patients with controlled hypertension (n= 9 in each of the two groups) were those with normal blood pressure levels (systolic blood pressure below 139 mmHg). Patients with uncontrolled hypertension (n= 6 in each of the two groups) were those with high blood pressure levels despite medication (systolic blood pressure above 160 mmHg). Anesthesia was maintained with either 1.0 minimum alveolar concentration (MAC) of sevoflurane or 1.0 MAC of isoflurane in 33% oxygen and 67% nitrous oxide. A 2.5-MHz pulsed transcranial Doppler probe was attached to the patient's head at the right temporal window for continuous measurement of the mean blood flow velocity in the middle cerebral artery (V(mca)). After establishing baseline values of V(mca) and cardiovascular hemodynamics, the end-tidal CO(2) was increased by decreasing the ventilatory frequency by 2-5 breaths per minute. RESULTS: Values of the absolute and relative CO(2) reactivity in the sevoflurane groups were lower than those in the isoflurane groups. There were no significant intra-group differences in the absolute and relative CO(2) reactivity within the sevoflurane and isoflurane groups. CONCLUSIONS: Our findings suggest that, in hypertensive patients, the control of cerebral blood flow by altering the pressure of arterial CO(2) (P(a)co(2)) can be more effectively achieved during isoflurane rather than sevoflurane anesthesia.
Authors:
Y Kadoi; S Saito; K Takahashi
Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-20
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  51     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-19     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1382-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Gunma University Hospital, Gunma, Japan. kadoi@med.gunma-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Brain / blood supply,  drug effects*,  metabolism*
Carbon Dioxide / blood*
Health
Humans
Hypertension / blood*,  drug therapy*
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Middle Aged
Chemical
Reg. No./Substance:
0/Methyl Ethers; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Limitations of arterial pulse pressure variation and left ventricular stroke volume variation in est...
Next Document:  The successful use of recombinant factor VIIa in a patient with vascular-type Ehlers-Danlos syndrome...