Document Detail

A comparative cytopathologic study of noninvasive and invasive squamous cell carcinoma of the lung.
MedLine Citation:
PMID:  546279     Owner:  NLM     Status:  MEDLINE    
Atypical cells and tissue fragments from the sputum of patients with early and advanced stages of squamous cell carcinoma of the bronchus are objectively characterized and quantitatively compared in this paper. Four classes of single-cell features of cytoplasm, nucleus, nucleolus and nuclear-cytoplasmic ratio are analyzed as a function of cell size and tumor development stage. Distinct differences in the cellular patterns are observed which may enhance cytologic discrimination between noninvasive and invasive stages of squamous cell carcinoma of the bronchus. Initial results justify the application of more sensitive measurement techniques (i.e., automated cytology) to an enlarged data base.
Y S Erozan; N J Pressman; P A Donovan; P K Gupta; J K Frost
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Analytical and quantitative cytology     Volume:  1     ISSN:  0190-0471     ISO Abbreviation:  Anal Quant Cytol     Publication Date:    1979 Mar-Apr
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911206     Medline TA:  Anal Quant Cytol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
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MeSH Terms
Carcinoma in Situ / pathology*
Carcinoma, Bronchogenic / pathology*
Carcinoma, Squamous Cell / pathology*
Cell Nucleolus / pathology
Cell Nucleus / pathology
Chromatin / analysis
Cytoplasm / pathology
Lung Neoplasms / pathology*
Neoplasm Invasiveness
Sputum / cytology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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