Document Detail

A comparative clinical study of injection clonidine versus midazolam in supraclavicular brachial plexus block for sedation and postoperative analgesia: a study of 60 cases.
MedLine Citation:
PMID:  21510527     Owner:  NLM     Status:  MEDLINE    
A randomised clinical study was conducted in 60 ASA I-II patients undergoing elective upper limb orthopaedic surgeries (duration of surgery < or =120 minutes). All the patients were divided into two groups (n=30 each), group C (clonidine) and group M (midazolam). All were premedicated with injection glycopyrrolate 0.2 mg intramuscular 30 minutes before surgery and given injection bupivacaine 0.5% plain 20 ml and injection lignocaine 2% plain 10 ml in supraclavicular brachial plexus block. In group C patients injection clonidine 150 mcg and in group M injection midazolam preservative free 5 mg were administered along with local anaesthetics. All the patients were observed for onset and duration of sensory and motor blockade, sedation score, postoperative analgesia with visual analogue scale (VAS) score up to 12 hours. There was no clinically significant difference in onset and duration of sensory and motor blockade among both the study groups. Intra-operative haemodynamic monitoring with non-invasive blood pressure, pulse rate, ECG, and Sp(o2) was done. In group C more sedation (score 2) was observed compared to group M (score 1) though the data is not statistically significant. Postoperative analgesia was more prolonged in group C (VAS score < or =3 for 360 minutes) as compared to group M (VAS score < or =3 for 300 minutes), time of rescue analgesia was noticed in the form of patient demand analgesia (VAS score > or =3) and injection diclofenac 75 mg intramuscular was given. In group C 22 patients required only 1 dose while 7 patients required 2 doses and only 1 patient required 3 doses in 24 hours. In group M 5 patients required 1 dose and 23 patients required 2 doses and 2 patients required 3 doses in 24hours, though the data was not statistically significant. No complication was observed in any patient in both the groups. So injection clonidine provides better postoperative analgesia and more sedation than midazolam.
Vandana Trivedi; Nirav Patel
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  108     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2011-04-22     Completed Date:  2011-06-02     Revised Date:  2011-09-06    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  563-7     Citation Subset:  IM    
Department of Anaesthesiology, Shri MP Shah Medical College, Jamnagar 361008.
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MeSH Terms
Analgesia / methods*
Analgesics / administration & dosage*
Brachial Plexus
Bupivacaine / administration & dosage
Clonidine / administration & dosage*
Conscious Sedation / methods*
Hypnotics and Sedatives / administration & dosage*
Lidocaine / administration & dosage
Midazolam / administration & dosage*
Middle Aged
Nerve Block / methods*
Pain Measurement
Pain, Postoperative / prevention & control
Postoperative Period
Time Factors
Young Adult
Reg. No./Substance:
0/Analgesics; 0/Hypnotics and Sedatives; 137-58-6/Lidocaine; 2180-92-9/Bupivacaine; 4205-90-7/Clonidine; 59467-70-8/Midazolam
Comment In:
J Indian Med Assoc. 2011 Jan;109(1):49   [PMID:  21888164 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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