| A comparative analysis of major clinical outcomes using drug-eluting stents versus bare-metal stents in a large consecutive patient cohort. | |
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MedLine Citation:
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PMID: 20839351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To ascertain the long-term safety, efficacy, and pattern of use of drug-eluting stents (DES) in routine clinical practice. METHODS: We analyzed a registry of 6,583 consecutive patients undergoing percutaneous coronary intervention (PCI), of whom 2,633 were treated using DES (DES group) and 3,950 were treated using bare-metal stents (BMS group). Propensity score was used for stratified analysis of outcomes and for matching. Outcomes were total mortality, myocardial infarction (MI), repeat target vessel revascularization (TVR) rates, and risk-adjusted event-free survival. RESULTS: Follow-up time was 6 months to 5.18 years (mean: 3 years). Patients in the DES group were more likely to be diabetic and had use of longer or more stents, treatment of more lesions and of more proximal main vessels. After propensity score matching, the cumulative mortality was 12.85% in the DES group versus 14.14% in the BMS group (P = 0.001). Use of DES reduced the occurrence of MI (5.17% vs.5.83%, P = 0.046), of clinically driven TVR (9.76% vs. 12.28%, P < 0.001) and of the composite endpoint of death/MI/TVR (23.38% vs. 26.07%; P < 0.001). CONCLUSIONS: Our risk-adjusted event-free survival analysis indicates a prognostic benefit for DES utilization that sustains up to 5 years following PCI. |
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Authors:
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Tamir Bental; Abid Assali; Hana Vaknin-Assa; Eli I Lev; David Brosh; Shmuel Fuchs; Alexander Battler; Ran Kornowski |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 76 ISSN: 1522-726X ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 374-80 Citation Subset: IM |
Affiliation:
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Cardiology Department, Rabin Medical Center, Tel-Aviv University, Israel. tamir_b@zahav.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary / adverse effects, instrumentation*, mortality, utilization Chi-Square Distribution Cohort Studies Disease-Free Survival Drug-Eluting Stents* / utilization Female Humans Israel Kaplan-Meier Estimate Linear Models Logistic Models Male Metals* Middle Aged Myocardial Infarction / etiology Physician's Practice Patterns Propensity Score Prosthesis Design Registries Risk Assessment Risk Factors Stents* / utilization Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Metals |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2010 Sep 1;76(3):381-2
[PMID:
20839352
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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