Document Detail

A comparative analysis of cognitive profiles and white-matter alterations using voxel-based diffusion tensor imaging between patients with Parkinson's disease dementia and dementia with Lewy bodies.
MedLine Citation:
PMID:  19828477     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite clinical and neuropsychological similarities between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), recent studies have demonstrated that structural and pathological changes are more severe in DLB than in PDD. METHODS: 19 patients with probable PDD and 18 patients with probable DLB who had a similar overall severity of dementia and demographic characteristics were examined by a standardised neuropsychological test and voxel-based analysis of fractional anisotropy (FA) using diffusion tensor imaging (DTI). RESULTS: The patients with DLB performed significantly worse in visual recognition memory, semantic fluency and ideomotor praxis than those with PDD (p<0.05). Compared with controls, the FA value in patients with PDD was significantly lower in bilateral frontal, left temporal and left parietal white matter. In patients with DLB, the pattern of FA reduction was similar to that of patients with PDD; however, white-matter abnormalities were more severe and extended into bilateral insular, bilateral posterior cingular and bilateral visual association regions. In a direct comparison between PDD and DLB, the FA value in patients with DLB was significantly decreased in bilateral posterior temporal, posterior cingular and bilateral visual association fibres extending into occipital areas. CONCLUSIONS: Despite global similarities in cognitive performance and white-matter pathology between DLB and PDD patients, those with DLB had more severely impaired frontal and temporal area-associated cognitive subsets, and more severe white-matter pathology in temporal and visual association fibres. These data suggest that differences in the underlying nature of PDD and DLB may exist with global similarities in their cognitive performance and white-matter pathology.
Ji E Lee; Hae-Jeong Park; BoSuk Park; Sook K Song; Young H Sohn; Jong Doo Lee; Phil Hyu Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-14
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  81     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  320-6     Citation Subset:  IM    
Department of Neurology and Brain Research Institute, Yonsei University Medical College, Seodaemun-gu, Seoul, 120-752, South Korea.
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MeSH Terms
Aged, 80 and over
Cerebral Cortex / pathology*
Dementia / diagnosis*
Diagnosis, Differential
Diffusion Tensor Imaging*
Dominance, Cerebral / physiology
Gyrus Cinguli / pathology*
Lewy Body Disease / diagnosis*
Middle Aged
Nerve Fibers, Myelinated / pathology
Neuropsychological Tests*
Parkinson Disease / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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