Document Detail


The comparative activity of twelve 4-quinolone antimicrobials against Haemophilus influenzae and Streptococcus pneumoniae.
MedLine Citation:
PMID:  2941258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The minimal inhibitory concentrations (MICs) of twelve 4-quinolone antimicrobials were determined for 100 isolates of Haemophilus influenzae (including 30 beta-lactamase producing strains) and 100 isolates of Streptococcus pneumoniae. MICs were determined using an agar dilution technique in Mueller-Hinton agar supplemented with 10% lysed horse blood. The inoculum used was approximately 10(4) colony-forming units, contained in 10 microliters of Mueller-Hinton broth, which was applied to the agar plates using a multipoint inoculator. Following inoculation, plates were incubated at 37 degrees C for 18 h in an atmosphere enriched to 10% carbon dioxide. The MIC of each antimicrobial for each isolate examined was determined as the lowest concentration of the antimicrobial which completely inhibited growth of the inoculum. The minimum concentrations required to inhibit the growth of 50% (MIC50) and 90% (MIC90) of the organisms examined were also determined. The more recently synthesised 4-quinolones showed considerably greater activity than nalidixic acid and pipemidic acid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae. There was no apparent difference between the MICs observed for beta-lactamase producing and non-beta-lactamase producing strains of Haemophilus influenzae. Ciprofloxacin was the most active 4-quinolone examined (MIC90 for Haemophilus influenzae 0.008 microgram/ml; Streptococcus pneumoniae 2 micrograms/ml). Clinical studies on a possible role for some of the more recently synthesised 4-quinolones in the management of patients with respiratory infection are indicated.
Authors:
G L Ridgway; M D O'Hare; D Felmingham; R N Grüneberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  11     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1985  
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Quinolones*
Anti-Infective Agents*
Cinoxacin / pharmacology
Ciprofloxacin
Enoxacin
Fluoroquinolones*
Haemophilus influenzae / drug effects*
Humans
Microbial Sensitivity Tests
Nalidixic Acid / analogs & derivatives*,  pharmacology
Naphthyridines / pharmacology
Norfloxacin / analogs & derivatives,  pharmacology
Ofloxacin
Oxazines / pharmacology
Oxolinic Acid / pharmacology
Pefloxacin
Pipemidic Acid / pharmacology
Quinolines / pharmacology
Quinolizines / pharmacology
Quinolones*
Streptococcus pneumoniae / drug effects*
Chemical
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Naphthyridines; 0/Oxazines; 0/Quinolines; 0/Quinolizines; 0/Quinolones; 14698-29-4/Oxolinic Acid; 28657-80-9/Cinoxacin; 389-08-2/Nalidixic Acid; 3Y1OT3J4NW/rosoxacin; 51940-44-4/Pipemidic Acid; 5TU5227KYQ/amifloxacin; 70458-92-3/Pefloxacin; 70458-96-7/Norfloxacin; 74011-58-8/Enoxacin; 82419-36-1/Ofloxacin; 85721-33-1/Ciprofloxacin; UVG8VSP2SJ/flumequine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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