Document Detail


A comparative 1H NMR study of mouse alpha(1-53) and beta(2-53) epidermal growth factors.
MedLine Citation:
PMID:  3260496     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The three-dimensional structure of the mouse epidermal growth factor (EGF) in solution was studied by comparison of the 1H NMR spectra of alpha EGF (1-53) and beta EGF (2-53, des-asparaginyl 1 form). Using pH dependence of chemical shifts and a two-dimensional difference spectrum, the effect of the N-terminal deletion was investigated based on the complete assignment of the proton resonances. The affected residues were all found to be located exactly in the triple-stranded, beta-sheet core in the N-terminal domain of the EGF molecule.
Authors:
D Kohda; C Kodama; R Kase; H Nomoto; K Hayashi; F Inagaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biochemistry international     Volume:  16     ISSN:  0158-5231     ISO Abbreviation:  Biochem. Int.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-08-03     Completed Date:  1988-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100311     Medline TA:  Biochem Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  647-54     Citation Subset:  IM    
Affiliation:
Department of Molecular Physiology, Tokyo Metropolitan Institute of Medical Science, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids
Animals
Epidermal Growth Factor* / isolation & purification
Magnetic Resonance Spectroscopy
Male
Mice
Protein Conformation
Submandibular Gland / analysis
Chemical
Reg. No./Substance:
0/Amino Acids; 62229-50-9/Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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