Document Detail


The compaction properties of polyethylene glycols.
MedLine Citation:
PMID:  2858559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanical properties of polyethylene glycol (PEG) powders of different average molecular weights have been characterized in terms of their yield pressure, determined from the densification of compacts by the method of Heckel. The yield pressure was found to be proportional to the molecular weight of the PEG. The densification which occurred during compaction was greater the lower the molecular weight. In terms of compact tensile strength, PEG 10 000 produced the greatest strength for a given pressure. This arises from its ability to deform plastically to form a compact and be of sufficient intrinsic strength to resist fracture during the diametral compression test. Higher molecular weights PEGs do not allow sufficient plastic flow during consolidation for their inherent higher strength to be used.
Authors:
A A Al-Angari; J W Kennerley; J M Newton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  37     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-05-23     Completed Date:  1985-05-23     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Hardness
Molecular Weight
Particle Size
Polyethylene Glycols*
Powders
Chemical
Reg. No./Substance:
0/Polyethylene Glycols; 0/Powders

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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