Document Detail


A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease.
MedLine Citation:
PMID:  22903151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer's disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. Demonstrating that aerobic exercise alters the AD process would have enormous public health implications. The purpose of this paper is to report the protocol of a current, community-based pilot study of aerobic exercise for AD to guide future investigation. This manuscript provides 1) an overview of possible benefits of exercise in those with dementia, 2) a rationale and recommendations for implementation of a community-based approach, 3) recommendation for implementation of similar study protocols, and 4) unique challenges in conducting an exercise trial in AD.
Authors:
Eric D Vidoni; Angela Van Sciver; David K Johnson; Jinghua He; Robyn Honea; Brian Haines; Jami Goodwin; M Pat Laubinger; Heather S Anderson; Patricia M Kluding; Joseph E Donnelly; Sandra A Billinger; Jeffrey M Burns
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-08-07
Journal Detail:
Title:  Contemporary clinical trials     Volume:  33     ISSN:  1559-2030     ISO Abbreviation:  Contemp Clin Trials     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-03-04     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging*
Alzheimer Disease / physiopathology,  prevention & control*
Cognition / physiology
Community-Based Participatory Research / organization & administration*
Exercise*
Female
Humans
Male
Middle Aged
Pilot Projects
Grant Support
ID/Acronym/Agency:
K01 AG035042/AG/NIA NIH HHS; K01 HD067318/HD/NICHD NIH HHS; K23 NS058252/NS/NINDS NIH HHS; KL2 TR000119/TR/NCATS NIH HHS; KL2RR033177/RR/NCRR NIH HHS; M01RR023940/RR/NCRR NIH HHS; P30 AG035982/AG/NIA NIH HHS; P30AG035982/AG/NIA NIH HHS; R01 AG033673/AG/NIA NIH HHS; R01 AG034614/AG/NIA NIH HHS; R01AG033673/AG/NIA NIH HHS; R01AG034614/AG/NIA NIH HHS; U10NS077356/NS/NINDS NIH HHS; UL1 TR000001/TR/NCATS NIH HHS; UL1RR033179/RR/NCRR NIH HHS
Comments/Corrections

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