| A common variant in DRD3 receptor is associated with autism spectrum disorder. | |
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MedLine Citation:
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PMID: 19058789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of specific and common genetic etiologies for autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) was investigated for 132 candidate genes in a two-stage design-association study. METHODS: 1,536 single nucleotide polymorphisms (SNPs) covering these candidate genes were tested in ASD (n = 144) and ADHD (n = 110) patients and control subjects (n = 404) from The Netherlands. A second stage was performed with those SNPs from Stage I reaching a significance threshold for association of p < .01 in an independent sample of ASD patients (n = 128) and controls (n = 124) from the United Kingdom and a Dutch ADHD (n = 150) and control (n = 149) sample. RESULTS: No shared association was found between ASD and ADHD. However, in the first and second ASD samples and in a joint statistical analysis, a significant association between SNP rs167771 located in the DRD3 gene was found (joint analysis uncorrected: p = 3.11 x 10(-6); corrected for multiple testing and potential stratification: p = .00162). CONCLUSIONS: The DRD3 gene is related to stereotyped behavior, liability to side effects of antipsychotic medication, and movement disorders and may therefore have important clinical implications for ASD. |
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Authors:
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Mariken de Krom; Wouter G Staal; Roel A Ophoff; Judith Hendriks; Jan Buitelaar; Barbara Franke; Maretha V de Jonge; Patrick Bolton; David Collier; Sarah Curran; Herman van Engeland; Jan M van Ree |
Publication Detail:
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Type: Journal Article Date: 2008-12-05 |
Journal Detail:
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Title: Biological psychiatry Volume: 65 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-13 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 625-30 Citation Subset: IM |
Affiliation:
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Department of Neuroscience and Pharmacology and Department of Child and Adolescent Psychiatry, Rudolph Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Attention Deficit Disorder with Hyperactivity / genetics* Autistic Disorder / genetics* Child Female Genome-Wide Association Study Humans Male Polymorphism, Single Nucleotide* Receptors, Dopamine D3 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DRD3 protein, human; 0/Receptors, Dopamine D3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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