Document Detail

A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease.
MedLine Citation:
PMID:  18459066     Owner:  NLM     Status:  MEDLINE    
Background Two single nucleotide polymorphisms (SNPs, rs10757278 and rs2383207) on chromosome 9p21 have been proved to be associated with myocardial infarction. We investigated whether these two genetic markers are determinants of early-onset coronary artery disease. Methods and results A total of 444 consecutive patients were studied including 212 cases with coronary stenosis >or=50% or previous myocardial infarction and 232 controls without documented coronary artery disease. Ligase detection reaction was performed to detect two SNPs. After adjustment of clinical parameters, significant associations were identified for the rs2383207 and rs10757278 SNPs, with A/G and G/G genetypes at rs10757278 and G/G genetype carriers at rs2383207 having a higher risk of early-onset coronary artery disease than carriers of A/A genotype (odds ratio [OR] 2.207, 95% CI: 1.069-4.394, P = 0.028; OR 3.051, 95% CI: 1.086-8.567, P = 0.004; OR 2.964, 95% CI: 1.063-8.265, P = 0.038, respectively). There were no associations between rs10757278 and rs2383207 genotypes and the severity of coronary artery disease (both P > 0.05). Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease. These markers may help the identification of patients at increased risk for early-onset coronary artery disease.
Zhong Chen; Qi Qian; Genshan Ma; Jiahong Wang; Xiaoli Zhang; Yi Feng; Chengxing Shen; Yuyu Yao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-06
Journal Detail:
Title:  Molecular biology reports     Volume:  36     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  889-93     Citation Subset:  IM    
Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, Nanjing, People's Republic of China.
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MeSH Terms
Age of Onset
Case-Control Studies
China / epidemiology
Chromosomes, Human, Pair 9 / genetics*
Coronary Artery Disease / epidemiology*,  genetics*
Gene Frequency
Genetic Predisposition to Disease*
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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