Document Detail

A common pathway for developmental glaucomas.
MedLine Citation:
PMID:  3328916     Owner:  NLM     Status:  MEDLINE    
In a clinicopathologic study of ten patients, utilizing a modified trabeculectomy technique for acquisition of histologic specimens, a high insertion of the iris was observed in four types of developmental glaucoma. A survey of the literature revealed additional developmental disorders with this abnormality of the anterior chamber angle. The common defect is believed to arise from a developmental arrest during the third trimester of gestation of tissues derived from cranial neural crest cells. The mechanism by which this developmental defect leads to aqueous outflow obstruction may, in some cases, be a paradoxical collapse of the trabecular meshwork and Schlemm's canal in response to contraction of the ciliary musculature, while other patients may have additional developmental abnormalities in the aqueous outflow system as the possible mechanism of glaucoma.
M B Shields
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transactions of the American Ophthalmological Society     Volume:  85     ISSN:  0065-9533     ISO Abbreviation:  Trans Am Ophthalmol Soc     Publication Date:  1987  
Date Detail:
Created Date:  1988-05-24     Completed Date:  1988-05-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7506106     Medline TA:  Trans Am Ophthalmol Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  222-37     Citation Subset:  IM    
Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina.
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MeSH Terms
Anterior Chamber / abnormalities
Anterior Eye Segment / abnormalities*
Ciliary Body / abnormalities,  ultrastructure
Glaucoma / embryology*,  surgery
Iris / abnormalities,  ultrastructure
Middle Aged
Trabecular Meshwork / abnormalities,  ultrastructure

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