Document Detail


A common immunoregulatory locus controls susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis in BALB/c mice.
MedLine Citation:
PMID:  9510176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that differential susceptibility to actively induced experimental allergic encephalomyelitis (EAE) and experimental allergic orchitis (EAO) exists among various BALB/c substrains. Of eight substrains studied for EAE and 13 for EAO, BALB/cJ mice are phenotypically the most resistant to disease induction. Resistance to both diseases is controlled by single recessive mutations unlinked to any of the known alleles distinguishing BALB/cJ mice. In this study, segregation analysis employing a second generation backcross population shows that resistance to both EAE and EAO is due to a mutation in a common immunoregulatory gene. The role of immunoregulatory cells in controlling EAE resistance was examined using adoptive transfer protocols. BALB/cJ mice immunized with spinal cord homogenate plus adjuvants generate immunoregulatory spleen cells (SpC) that, when transferred to naive BALB/cByJ recipients, reduce the incidence and severity of EAE. Treatment of such cells with either cytotoxic monoclonal anti-Thy1.2 or anti-CD4 plus C' before transfer abrogates the ability of BALB/cJ SpC to inhibit disease. In contrast, neither SpC from adjuvant-immunized BALB/cJ nor spinal cord homogenate- plus adjuvant-primed BALB/cByJ donors influences the incidence or severity of disease observed in recipients. In addition, the role of environment in influencing susceptibility to EAE and EAO in BALB/c mice is documented. Taken together, these results support the existence of a common disease susceptibility locus in the pathways leading to two autoantigenically distinct CD4+ T cell-mediated, organ-specific, autoimmune diseases.
Authors:
C Teuscher; W F Hickey; C M Grafer; K S Tung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  160     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2751-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana 61802, USA. cteusche@staff.uiuc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / genetics*,  immunology
CD4-Positive T-Lymphocytes / immunology
Encephalomyelitis, Autoimmune, Experimental / genetics*,  immunology
Female
Genetic Predisposition to Disease*
Male
Mice
Mice, Inbred BALB C
Mutation
Orchitis / genetics*,  immunology
Organ Specificity
Grant Support
ID/Acronym/Agency:
HD21926/HD/NICHD NIH HHS; HD27275/HD/NICHD NIH HHS; NS36526/NS/NINDS NIH HHS

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