Document Detail


A common, high-dimensional model of the representational space in human ventral temporal cortex.
MedLine Citation:
PMID:  22017997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a high-dimensional model of the representational space in human ventral temporal (VT) cortex in which dimensions are response-tuning functions that are common across individuals and patterns of response are modeled as weighted sums of basis patterns associated with these response tunings. We map response-pattern vectors, measured with fMRI, from individual subjects' voxel spaces into this common model space using a new method, "hyperalignment." Hyperalignment parameters based on responses during one experiment--movie viewing--identified 35 common response-tuning functions that captured fine-grained distinctions among a wide range of stimuli in the movie and in two category perception experiments. Between-subject classification (BSC, multivariate pattern classification based on other subjects' data) of response-pattern vectors in common model space greatly exceeded BSC of anatomically aligned responses and matched within-subject classification. Results indicate that population codes for complex visual stimuli in VT cortex are based on response-tuning functions that are common across individuals.
Authors:
James V Haxby; J Swaroop Guntupalli; Andrew C Connolly; Yaroslav O Halchenko; Bryan R Conroy; M Ida Gobbini; Michael Hanke; Peter J Ramadge
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  72     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2011-12-19     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  404-16     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping / methods*
Functional Neuroimaging
Humans
Image Processing, Computer-Assisted
Models, Neurological
Neurons / physiology*
Photic Stimulation
Temporal Lobe / physiology*
Visual Cortex / physiology*
Visual Perception / physiology*
Grant Support
ID/Acronym/Agency:
5R01MH075706/MH/NIMH NIH HHS; F32 MH085433-01A1/MH/NIMH NIH HHS; F32 MH085433-02/MH/NIMH NIH HHS; F32 MH085433-03/MH/NIMH NIH HHS; F32MH085433-01A1/MH/NIMH NIH HHS; R01 MH075706/MH/NIMH NIH HHS; R01 MH075706-01A1/MH/NIMH NIH HHS; R01 MH075706-02/MH/NIMH NIH HHS; R01 MH075706-03/MH/NIMH NIH HHS; R01 MH075706-04/MH/NIMH NIH HHS; R01 MH075706-05/MH/NIMH NIH HHS; R01 MH075706-06/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Neuron. 2011 Oct 20;72(2):199-201   [PMID:  22017984 ]

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