Document Detail


A common genetic variant is associated with adult and childhood obesity.
MedLine Citation:
PMID:  16614226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
Authors:
Alan Herbert; Norman P Gerry; Matthew B McQueen; Iris M Heid; Arne Pfeufer; Thomas Illig; H-Erich Wichmann; Thomas Meitinger; David Hunter; Frank B Hu; Graham Colditz; Anke Hinney; Johannes Hebebrand; Kerstin Koberwitz; Xiaofeng Zhu; Richard Cooper; Kristin Ardlie; Helen Lyon; Joel N Hirschhorn; Nan M Laird; Marc E Lenburg; Christoph Lange; Michael F Christman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  312     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-04-27     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-83     Citation Subset:  IM    
Affiliation:
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA. aherbert@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Alleles
Body Mass Index*
Case-Control Studies
Child
Cohort Studies
Europe
European Continental Ancestry Group
Female
Gene Frequency
Genes, Recessive
Genetic Predisposition to Disease
Genetic Variation*
Genotype
Haplotypes
Humans
Intracellular Signaling Peptides and Proteins / genetics
Linkage Disequilibrium
Male
Membrane Proteins / genetics
Models, Genetic
Obesity / genetics*
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide*
Grant Support
ID/Acronym/Agency:
CA87969/CA/NCI NIH HHS; K23DK067288/DK/NIDDK NIH HHS; P30DK46200/DK/NIDDK NIH HHS; R01 HD060726/HD/NICHD NIH HHS; R01GM046877/GM/NIGMS NIH HHS; R01HL074166/HL/NHLBI NIH HHS; R01HL54485/HL/NHLBI NIH HHS; R01HL66289/HL/NHLBI NIH HHS; R01MH59532/MH/NIMH NIH HHS; U01HL65899/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/INSIG2 protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins
Comments/Corrections
Comment In:
Science. 2007 Jan 12;315(5809):187; author reply 187   [PMID:  17218509 ]
Science. 2007 Jan 12;315(5809):187; author reply 187   [PMID:  17218508 ]
Science. 2007 Jan 12;315(5809):187; author reply 187   [PMID:  17218510 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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