| A commercial pregnancy test modified for field studies of fetal loss. | |
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MedLine Citation:
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PMID: 9564555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe simple modifications to the ICON II hCG (URINE) pregnancy test to provide a sensitive and specific urinary assay for hCG in field studies of fetal loss. The modified assay had a qualitative lower limit of detection of 0.30 IU/l, a 50% qualitative limit of 0.61 IU/l, a 100% qualitative limit of 1.16 IU/l, and a quantitative limit of 0.80 IU/l. Coefficients of variation ranged from 9.9% to 21.1%. Parallelism was observed among serially diluted subject samples. We used the assay in an 11-month prospective study of fetal loss in rural Bangladesh in which urine samples were collected twice-weekly from 494 women; 330 pregnancies and 93 fetal losses were detected. The median time to a positive pregnancy diagnosis was day 26 from last menses. The modified assay provided qualitative detection of early pregnancy comparable to laboratory assays, and appears to be well suited for use in epidemiologic or rural-population fetal loss studies. |
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Authors:
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D J Holman; F N Rasheed; C M Stroud; E Brindle; K A O'Connor; K L Campbell |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 271 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-06-04 Completed Date: 1998-06-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 25-44 Citation Subset: IM |
Affiliation:
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Department of Anthropology, Pennsylvania State University, University Park 16802, USA. holman@pop.psu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Bangladesh Chorionic Gonadotropin / urine* Female Fetal Death / epidemiology* Humans Immunoassay / methods Menstruation / physiology Middle Aged Pregnancy Pregnancy Tests, Immunologic / methods* Reagent Kits, Diagnostic Reference Standards Sensitivity and Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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1HD28263-01/HD/NICHD NIH HHS; F32HD07994-02/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Reagent Kits, Diagnostic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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