Document Detail


A commentary on clinical trials in chronic heart failure.
MedLine Citation:
PMID:  16959759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heart failure is a common condition and becoming more common. Many treatments have been evaluated in large clinical trials during the last few decades. These trials can be criticized but do provide an evidence base for treatment, probably greater than for most other clinical conditions. Weaknesses exist in relation to age, ejection fraction, and gender. Most trials have included patients 10 years younger than those in the general population. There is little evidence for efficacy in patients with a near normal ejection fraction. Few women have been included in trials.
Authors:
Philip A Poole-Wilson; Alexander R Lyon; Adam M Jacques
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in cardiothoracic and vascular anesthesia     Volume:  10     ISSN:  1089-2532     ISO Abbreviation:  Semin Cardiothorac Vasc Anesth     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2007-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9807630     Medline TA:  Semin Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  242-5     Citation Subset:  IM    
Affiliation:
Department of Cardiac Medicine, National Heart & Lung Institute, Imperial College London, London, United Kingdom. p.poole-wilson@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use
Angiotensin II Type 1 Receptor Blockers / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Clinical Trials as Topic
Diuretics / therapeutic use
Heart Failure / drug therapy*,  epidemiology
Humans
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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