| A commensal symbiosis between Prevotella bivia and Peptostreptococcus anaerobius involves amino acids: potential significance to the pathogenesis of bacterial vaginosis. | |
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MedLine Citation:
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PMID: 9879923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In both batch and continuous culture, Peptostreptococcus anaerobius was able to grow in vaginal defined medium with Prevotella bivia, but not in pure culture. Growth of P. anaerobius was increased by 238% (P < 0.001) in peptone-supplemented vaginal defined medium conditioned by prior growth of P. bivia. Analysis of P. bivia culture supernatants showed a net accumulation of amino acids and subsequent growth of P. anaerobius in the conditioned supernatants resulted generally in amino acid utilization. Supplementation of peptone-supplemented vaginal defined medium with amino acids in concentrations similar to those available after prior growth with P. bivia were growth-stimulatory (246%, P=0.006) for P. anaerobius. Increased availability of amino acids by P. bivia is proposed as a mechanism to support the observed in vitro commensal symbiosis between P. bivia and P. anaerobius. |
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Authors:
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V Pybus; A B Onderdonk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: FEMS immunology and medical microbiology Volume: 22 ISSN: 0928-8244 ISO Abbreviation: FEMS Immunol. Med. Microbiol. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9315554 Medline TA: FEMS Immunol Med Microbiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 317-27 Citation Subset: IM |
Affiliation:
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Channing Laboratory, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02215, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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analysis,
physiology* Culture Media, Conditioned Female Humans Peptostreptococcus / growth & development*, metabolism Prevotella / growth & development*, metabolism Symbiosis Vaginosis, Bacterial / microbiology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Culture Media, Conditioned |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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