Document Detail

A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone; naloxone reverses these effects.
MedLine Citation:
PMID:  7402686     Owner:  NLM     Status:  MEDLINE    
The D-amino acids (DAA), D-phenylalanine and D-leucine, produce naloxone reversible analgesia; electroacupuncture (EA) also produces analgesia which is blocked by naloxone. Combining the two treatments produces an additive effect with a larger analgesia than that produced by either treatment given alone; this combined effect is also blocked by naloxone. Moreover only 62% of the mice show EA analgesia and 53% show D-amino acid (DAA) analgesia; 80% of the animals show marked analgesia with both EA plus DAA treatment. Perhaps the combination of EA with DAA will provide a potent method for the treatment of clinical pain.
R S Cheng; B Pomeranz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pain     Volume:  8     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-10-27     Completed Date:  1980-10-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  231-6     Citation Subset:  IM    
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MeSH Terms
Acupuncture Therapy*
Electric Stimulation
Leucine / therapeutic use*
Naloxone / pharmacology
Pain / therapy
Phenylalanine / therapeutic use*
Reg. No./Substance:
465-65-6/Naloxone; 61-90-5/Leucine; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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