| A combined dexamethasone/corticotropin-releasing hormone test in patients with chronic PTSD--first preliminary results. | |
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MedLine Citation:
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PMID: 17884095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Reports about alterations of hypothalamic-pituitary-adrenocortical (HPA) function in patients with chronic posttraumatic stress disorder (PTSD) are inconsistent and controversial. More refined laboratory tests and subgrouping of PTSD patients might help to decrease variance of findings. METHODS: 14 subjects with chronic PTSD and 14 healthy controls were examined between 13:00 and 17:00 using a modified combined dexamethasone/CRH test (0.5 mg dexamethasone at 23:00, 100 microg CRH at 15:00). Plasma adenocorticotropic hormone (ACTH), cortisol and blood pressure were measured every 15 min from 14:45 until 17:00. RESULTS: No significant differences between patients and controls were found in the analyses of ACTH and cortisol levels, but a significantly elevated systolic and diastolic blood pressure in PTSD. Severity of depressive symptoms had no influence. However, explorative analyses showed that patients with a history of childhood traumatization had significantly higher post-dexamethasone-ACTH levels and a significantly lower diastolic blood pressure in comparison to patients without early trauma. CONCLUSIONS: In this first pilot study in a typical clinical sample of patients with chronic PTSD we found effects of severe adverse events in childhood on HPA axis regulation. Maybe, childhood traumatization could influence HPA axis findings in PTSD. Further research is needed, especially dose-response studies with different doses of dexamethasone in dexamethasone/CRH tests in PTSD. |
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Authors:
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Christoph Muhtz; Monika Wester; Alexander Yassouridis; Klaus Wiedemann; Michael Kellner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-19 |
Journal Detail:
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Title: Journal of psychiatric research Volume: 42 ISSN: 0022-3956 ISO Abbreviation: J Psychiatr Res Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-04-25 Completed Date: 2008-08-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376331 Medline TA: J Psychiatr Res Country: England |
Other Details:
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Languages: eng Pagination: 689-93 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. cmuhtz@uke.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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blood* Adult Blood Pressure / physiology Child Child Abuse / psychology, statistics & numerical data Chronic Disease Circadian Rhythm / physiology Comorbidity Control Groups Corticotropin-Releasing Hormone / diagnostic use* Depressive Disorder, Major / diagnosis, epidemiology, psychology Dexamethasone / diagnostic use* Female Humans Hydrocortisone / blood* Hypothalamo-Hypophyseal System / physiopathology Life Change Events Male Middle Aged Pilot Projects Pituitary-Adrenal System / physiopathology Severity of Illness Index Stress Disorders, Post-Traumatic / blood, diagnosis*, physiopathology |
| Chemical | |
Reg. No./Substance:
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50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone |
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