Document Detail

The combined effect of ultrasound exposure and cisplatin on human ovarian carcinoma cells A2780.
MedLine Citation:
PMID:  18647549     Owner:  NLM     Status:  MEDLINE    
This article deals with an in vitro study of the effect of cisplatin and low intensity ultrasound exposure on the viability of human ovarial carcinoma cells A2780. The effect on the viability of 103 cell experimental group samples under the influence of separate and combined cisplatin and ultrasound far field exposure was studied. Viable cells in individual experimental groups were followed at time intervals of 0, 24, 48 and 72 hours following treatment. Another objective of the study was to investigate the effect of the experimental protocol on the combined effect of cisplatin and ultrasound exposure. The effect of the concurrent application of cisplatin and ultrasound exposure was compared with that in which cisplatin was added to the cell suspension after ultrasound exposure. The results of this work confirmed the cytotoxicity of cisplatin and possible stimulation of cancer cells by low intensity ultrasound. However, it was found that ultrasound exposure enhances the action of cisplatin on the viability of A2780 cells and that the effect is dependent on the experimental protocol. In this case the concurrent application of cisplatin and ultrasound was found to be more effective (P < 0.05).
V Bernard; J Skorpíková; V Mornstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia biologica     Volume:  54     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-23     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  97-101     Citation Subset:  IM    
Department of Biophysics, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Survival
Cisplatin / pharmacology*
Combined Modality Therapy
Ovarian Neoplasms / metabolism,  pathology,  therapy*
Ultrasonic Therapy*
Reg. No./Substance:
0/Antineoplastic Agents; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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