Document Detail


Chloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeastern Irian Jaya, Indonesia.
MedLine Citation:
PMID:  11463107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combination therapy is one method of overcoming the global challenge of drug-resistant Plasmodium falciparum malaria. We conducted a hospital-based 28-day in vivo test comparing chloroquine/doxycycline to chloroquine or doxycycline alone for treating P. falciparum and Plasmodium vivax malaria in Irian Jaya, Indonesia. Eighty-nine patients with uncomplicated falciparum malaria were randomized to standard dose chloroquine (n = 30), doxycycline (100 mg every 12 hours [7 days], n = 20), or chloroquine with doxycycline (n = 39); corresponding numbers for vivax malaria (n = 63) were 23, 16, 24. Endpoints were parasite sensitivity (S) or resistance (RI/RII/RIII). Of the 105 evaluable patients, chloroquine/doxycycline cured (S) 20/22 (90.9% [95% CI 78.9-100%]) patients with P. falciparum malaria; 2/22 (9.1% [0-21%]) were RIII resistant. Doxycycline cured 11/17 (64.7% [42.0-87.4%]) patients, and chloroquine 4/20 (20% [2.5-37.5%]). Against P. vivax, chloroquine/doxycycline cured (S) 12/17 (70.6% [48.9-92.2%]) patients, doxycycline 4/12 (33.3% [6.6-59.9%]), and chloroquine 5/17 (29.4% [7.7-51.1%]). Chloroquine/doxycycline was effective against P. falciparum but only modestly effective against P. vivax. These findings support the use of chloroquine/doxycycline as an inexpensive alternative to mefloquine for treating chloroquine-resistant P. falciparum but not chloroquine-resistant P. vivax in this setting.
Authors:
W R Taylor; H Widjaja; T L Richie; H Basri; C Ohrt; Tjitra; E Taufik; T R Jones; K C Kain; S L Hoffman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  64     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-07-20     Completed Date:  2001-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  AIM; IM    
Affiliation:
United States Naval Medical Research Unit Number 2, Jakarta, Indonesia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antimalarials / administration & dosage,  blood,  therapeutic use*
Chloroquine / administration & dosage,  blood,  therapeutic use*
Doxycycline / administration & dosage,  therapeutic use*
Drug Therapy, Combination
Female
Humans
Indonesia
Malaria / drug therapy*,  parasitology
Male
Plasmodium falciparum / isolation & purification*
Plasmodium vivax / isolation & purification*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine; 564-25-0/Doxycycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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