| Chloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeastern Irian Jaya, Indonesia. | |
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MedLine Citation:
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PMID: 11463107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Combination therapy is one method of overcoming the global challenge of drug-resistant Plasmodium falciparum malaria. We conducted a hospital-based 28-day in vivo test comparing chloroquine/doxycycline to chloroquine or doxycycline alone for treating P. falciparum and Plasmodium vivax malaria in Irian Jaya, Indonesia. Eighty-nine patients with uncomplicated falciparum malaria were randomized to standard dose chloroquine (n = 30), doxycycline (100 mg every 12 hours [7 days], n = 20), or chloroquine with doxycycline (n = 39); corresponding numbers for vivax malaria (n = 63) were 23, 16, 24. Endpoints were parasite sensitivity (S) or resistance (RI/RII/RIII). Of the 105 evaluable patients, chloroquine/doxycycline cured (S) 20/22 (90.9% [95% CI 78.9-100%]) patients with P. falciparum malaria; 2/22 (9.1% [0-21%]) were RIII resistant. Doxycycline cured 11/17 (64.7% [42.0-87.4%]) patients, and chloroquine 4/20 (20% [2.5-37.5%]). Against P. vivax, chloroquine/doxycycline cured (S) 12/17 (70.6% [48.9-92.2%]) patients, doxycycline 4/12 (33.3% [6.6-59.9%]), and chloroquine 5/17 (29.4% [7.7-51.1%]). Chloroquine/doxycycline was effective against P. falciparum but only modestly effective against P. vivax. These findings support the use of chloroquine/doxycycline as an inexpensive alternative to mefloquine for treating chloroquine-resistant P. falciparum but not chloroquine-resistant P. vivax in this setting. |
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Authors:
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W R Taylor; H Widjaja; T L Richie; H Basri; C Ohrt; Tjitra; E Taufik; T R Jones; K C Kain; S L Hoffman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 64 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2001 May-Jun |
Date Detail:
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Created Date: 2001-07-20 Completed Date: 2001-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 223-8 Citation Subset: AIM; IM |
Affiliation:
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United States Naval Medical Research Unit Number 2, Jakarta, Indonesia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Antimalarials / administration & dosage, blood, therapeutic use* Chloroquine / administration & dosage, blood, therapeutic use* Doxycycline / administration & dosage, therapeutic use* Drug Therapy, Combination Female Humans Indonesia Malaria / drug therapy*, parasitology Male Plasmodium falciparum / isolation & purification* Plasmodium vivax / isolation & purification* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 54-05-7/Chloroquine; 564-25-0/Doxycycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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