Document Detail

A combination therapy of vitamin K1 and bile acid on hemorrhagic diathesis in patients with decompensated liver cirrhosis.
MedLine Citation:
PMID:  3384277     Owner:  NLM     Status:  MEDLINE    
This paper presents a study of treatment involving vitamin K1 (VK1) accompanied by bile acids for hemorrhagic diathesis that was applied 42 times in 35 patients with decompensated liver cirrhosis. The hepaplastin test (HPT) value showed no change during the administration of VK1 alone. The HPT value elevated significantly, however, after the administration of VK1 with bile acid, especially when using ursodeoxycholic acid (UDCA). The HPT value in patients treated with VK1 in addition to UDCA before treatment with 53.2% +/- 10.2% (mean +/- SD) and after that for 2.1 +/- 1.1 months (mean +/- SD) with 74.7 +/- 16.8% showed a significant difference (p less than 0.001). On the other hand, no significant difference was noted between the HPT value of 57.2 +/- 13.6% before and that of 62.9 +/- 13.9% after the treatment in patients treated using VK1 in conjunction with chenodeoxycholic acid (CDCA). These results indicate that the therapy incorporating VK1 and bile acid, especially UDCA, is useful for reducing the hemorrhagic tendency in patients with decompensated liver cirrhosis who show no improvement using VK1 alone.
M Nambu; T Iijima
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastroenterologia Japonica     Volume:  23     ISSN:  0435-1339     ISO Abbreviation:  Gastroenterol. Jpn.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-29     Completed Date:  1988-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0152744     Medline TA:  Gastroenterol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
Department of Internal Medicine, Urayasu Hospital of Juntendo University School of Medicine, Chiba, Japan.
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MeSH Terms
Chenodeoxycholic Acid / therapeutic use*
Deoxycholic Acid / analogs & derivatives*
Drug Therapy, Combination
Hemorrhagic Disorders / drug therapy*,  etiology
Liver Cirrhosis / complications*
Ursodeoxycholic Acid / therapeutic use*
Vitamin K / therapeutic use*
Reg. No./Substance:
12001-79-5/Vitamin K; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; 83-44-3/Deoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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