Document Detail

The combination of partial liquid ventilation and inhaled nitric oxide in the severe oleic acid lung injury model.
MedLine Citation:
PMID:  9631808     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To elucidate the efficacy of the combination of inhaled nitric oxide (NO) and partial liquid ventilation (PLV) in ARDS. DESIGN: Prospective, randomized, controlled study. SETTING: A research laboratory at a university medical center. SUBJECTS: Thirty-two rabbits. INTERVENTIONS: Animals were anesthetized and ventilated via tracheostomy (tidal volume=40 mL; respiratory rate=25 breaths/min; fraction of inspired oxygen=0.99). After 0.08 mL/kg (0.071 g/kg) oleic acid was administered via the central venous route, animals were randomly divided into the following four groups depending on the ventilatory mode: (1) Gas ventilation (GV)-control group: GV was continued throughout the study; (2) GV-NO group: NO inhalation (10 ppm) was performed under GV; (3) PLV-control group: PLV using perflubron (15 mL/kg) was continued until the end of the study; and (4) PLV-NO group: NO inhalation (10 ppm) was performed under PLV. MEASUREMENTS AND RESULTS: NO inhalation improved PaO2 in the PLV-NO group (from 133+/-20 to 167+/-23 mm Hg; p=0.0008), but not in the GV-NO group (from 67+/-6 to 63+/-9 mm Hg), although pulmonary vascular resistance decreased both in the GV-NO (from 4,604+/-328 to 4,337+/-322 dyne x s x cm(-5); p=0.0116) and the PLV-NO group (from 4,727+/-665 to 4,112+/-560 dyne x s x cm(-5); p=0.0036). (Data were expressed as mean+/-SEM.) CONCLUSION: PLV augmented the effect of inhaled NO on pulmonary gas exchange. The combination of PLV and NO inhalation could be effective in severe ARDS.
T Uchida; K Nakazawa; K Yokoyama; K Makita; K Amaha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  113     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-06     Completed Date:  1998-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1658-66     Citation Subset:  AIM; IM    
Department of Anesthesiology and Critical Care Medicine, Tokyo Medical and Dental University, School of Medicine, Japan.
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MeSH Terms
Carbon Dioxide / blood
Fluorocarbons / administration & dosage*
Nitric Oxide / administration & dosage*
Oleic Acid
Oxygen / blood
Pulmonary Circulation
Pulmonary Edema / chemically induced,  physiopathology,  therapy*
Respiration, Artificial* / methods
Vascular Resistance
Reg. No./Substance:
0/Fluorocarbons; 10102-43-9/Nitric Oxide; 112-80-1/Oleic Acid; 124-38-9/Carbon Dioxide; 423-55-2/perflubron; 7782-44-7/Oxygen

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