Document Detail

A combination of oral cabergoline and double cloprostenol injections to produce third-quarter gestation termination in the bitch.
MedLine Citation:
PMID:  16960040     Owner:  NLM     Status:  MEDLINE    
To assess the efficacy and safety of a combined cabergoline and cloprostenol protocol to terminate third-quarter pregnancy, 22 pregnant bitches that ranged from 35 to 45 days after mating were randomly assigned to a treatment group (n=13) or to an untreated control group (n=9). The animals were monitored for 12 days, and pregnancy termination was confirmed by ultrasound examination. Twelve of the 13 treated bitches aborted within 9 days of the initiation of treatment (mean 4.6 days). Only mild side effects were observed. The control animals had normal gestational courses, as did the bitch that did not respond to the therapy. This combination of drugs appeared to be a practical, safe, and efficient abortifacient when used in third-quarter pregnancies.
Yanina Corrada; Raúl Rodríguez; Mariana Tortora; Daniel Arias; Cristina Gobello
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Animal Hospital Association     Volume:  42     ISSN:  1547-3317     ISO Abbreviation:  J Am Anim Hosp Assoc     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-09-08     Completed Date:  2008-07-08     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0415027     Medline TA:  J Am Anim Hosp Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
Imaging Diagnosis Service, Faculty of Veterinary Medicine, National University of La Plata, La Plata, Argentina.
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MeSH Terms
Abortifacient Agents / administration & dosage*
Abortion, Induced / methods,  veterinary*
Abortion, Veterinary / chemically induced*
Administration, Oral
Cloprostenol / administration & dosage
Dopamine Agonists / administration & dosage
Drug Therapy, Combination
Ergolines / administration & dosage
Injections, Subcutaneous / veterinary
Luteolytic Agents / administration & dosage
Pregnancy Outcome
Reg. No./Substance:
0/Abortifacient Agents; 0/Dopamine Agonists; 0/Ergolines; 0/Luteolytic Agents; 40665-92-7/Cloprostenol; LL60K9J05T/cabergoline

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