Document Detail

The combination of follicle-stimulating hormone and human menopausal gonadotropin for the induction of multiple follicular maturation for in vitro fertilization.
MedLine Citation:
PMID:  3924669     Owner:  NLM     Status:  MEDLINE    
One hundred fifty-one cycles in 134 consecutive patients were stimulated with 150 IU of human urinary follicle-stimulating hormone (FSH) and 150 IU of human menopausal gonadotropin (hMG) on cycle days 3 and 4 and then with 150 IU of hMG daily for the purpose of multiple follicular development for in vitro fertilization (IVF). Seventy-three patients did not have a prior IVF attempt, and 61 patients in 78 cycles had prior IVF attempts at least once with their previous cycles stimulated with the same method and/or hMG and/or FSH. There was an average of three preovulatory oocytes retrieved per laparoscopy and a pregnancy rate of 27% per transfer cycle. The results were equally favorable in "new" and "old" patient cycles. The pregnancy rate increased with the transfer of two or more conceptuses of preovulatory origin. The multiple pregnancy rate, but not the abortion rate, increased with increased numbers of conceptuses transferred.
S J Muasher; J E Garcia; Z Rosenwaks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  44     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-16     Completed Date:  1985-08-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-9     Citation Subset:  IM    
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MeSH Terms
Abortion, Spontaneous
Chorionic Gonadotropin / administration & dosage*
Drug Therapy, Combination
Embryo Transfer
Estradiol / blood
Fertilization in Vitro*
Follicle Stimulating Hormone / administration & dosage*
Luteal Phase
Menotropins / administration & dosage*
Oocytes / growth & development
Ovarian Follicle / growth & development*
Ovulation Induction / methods*
Pregnancy, Ectopic
Pregnancy, Multiple
Progesterone / blood
Time Factors
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 57-83-0/Progesterone; 61489-71-2/Menotropins; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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