| Lopinavir/ritonavir combination and total/HDL cholesterol ratio. | |
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MedLine Citation:
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PMID: 15780417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To describe the evolution of the lipidic profile among LPV/r treated patients in a 'real life' situation. METHODS: Lipids measurements at LPV/r initiation time and every 3 months, and pharmacological measurements at M3 and M6 were collected retrospectively in 142 patients attending our clinic. Dyslipidaemia was defined as total cholesterol > or =6.2 mmol/l, HDL-cholesterol > or =1 mmol/l, total/HDL-cholesterol ratio > or =6.5 and triglycerides > or =2.3 mmol/l. RESULTS: Eighty-nine percent of patients had previously received a regimen with protease inhibitors, 4% were treatment naive. At baseline, 17% of patients had high total cholesterol, 49% high triglycerides, 63% low HDL-cholesterol, 25% a high total/HDL-cholesterol ratio. At M12, the mean HDL-cholesterol increase per patient was 21%. Lipids levels significantly increased over the study period, as early as the 3rd month (6th month for ratio) and continuously until the 12th month. Among the patients with available LPV/r plasma determinations at M3, a higher lopinavir residual concentration was observed in those with high triglycerides (6.78 vs 3.02 mg/l, p = 0.05) as, at M6, in those with an elevated ratio (9.19 vs 0.96 mg/l, p = 0.02). CONCLUSIONS: Those results suggest that LPV/r may induce a significant rise in the total/HDL-cholesterol ratio, despite an increase in HDL-cholesterol levels. The association between triglycerides and total/HDL-cholesterol ratio elevated levels and high residual concentrations of lopinavir may also argue for systematic drug monitoring. |
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Authors:
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Laure Valerio; Eric Fontas; Christian Pradier; Thibaud Lavrut; Rodolphe Garraffo; Brigitte Dunais; Eric Cua; Pierre Dellamonica |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infection Volume: 50 ISSN: 0163-4453 ISO Abbreviation: J. Infect. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-22 Completed Date: 2005-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: IM |
Affiliation:
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Department of Public Health, Hôpital de l'Archet I, Centre Hospitalier Universitaire, Route de Saint Antoine de Ginestière, BP 3079-06202 Nice Cedex 3, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholesterol / blood Cholesterol, HDL / blood Drug Combinations Female HIV Infections / blood, drug therapy HIV Protease Inhibitors / adverse effects* Humans Hyperlipidemias / chemically induced* Male Middle Aged Pyrimidinones / administration & dosage, adverse effects*, blood Retrospective Studies Ritonavir / administration & dosage, adverse effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Drug Combinations; 0/HIV Protease Inhibitors; 0/Pyrimidinones; 0/Ritonavir; 192725-17-0/lopinavir; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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