| A color Doppler ultrasound-based comparative study between stavudine and non-stavudine regimens in the onset of vascular lesions in HIV-1-positive patients. | |
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MedLine Citation:
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PMID: 18712177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The present study aimed to investigate the role of stavudine in the onset of premature vascular lesions using an ultrasound color Doppler evaluation of the carotid vessels. PATIENTS AND METHODS: A total of 266 patients were evaluated: 149 were treated with stavudine (group I) and 117 without stavudine (group II). RESULTS: Of the patients in group I, 41% exhibited vascular lesions vs. 26% in group II (p=0.0103). The two groups were further divided into subgroups Ia (stavudine and proteinase inhibitor, PI), Ib (stavudine and non-nucleotidic reverse transcriptase inhibitor, NNRTI), IIa (PI, without stavudine) and IIb (NNRTI without stavudine). A higher prevalence of lesions emerged in group Ia, while group IIa were at higher risk of developing vascular lesions than groups Ib and IIb. CONCLUSION: Although stavudine per se does not seem to determine damage of the epiaortic vessels, the association of a PI with stavudine is related to a significantly higher rate of lesions. |
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Authors:
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Paolo Maggi; Antonio Chirianni; Antonio Lillo; Francesco Perilli; Miriam Gargiulo; Vincenzo Esposito; Chiara Bellacosa; Giuseppe Pastore; Guido Regina |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 22 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 489-92 Citation Subset: IM |
Affiliation:
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Clinica delle Malattie Infettive, Università di Bari, Italy. p_maggi@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anti-HIV Agents / therapeutic use* Child Female HIV Infections / complications*, drug therapy* HIV Seropositivity Humans Male Middle Aged Stavudine / therapeutic use* Treatment Outcome Ultrasonography, Doppler / methods* Vascular Diseases / complications*, drug therapy*, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 3056-17-5/Stavudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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