Document Detail

Granulocyte/macrophage colony-stimulating factor plays an essential role in oxidized low density lipoprotein-induced macrophage proliferation.
MedLine Citation:
PMID:  11425039     Owner:  NLM     Status:  MEDLINE    
We and other groups have recently demonstrated that oxidized low density lipoprotein (Ox-LDL) induces proliferation of macrophages in vitro. Since previous immunohistochemical studies demonstrated that macrophages and macrophage derived foam cells proliferated in situ in atherosclerotic lesions, it seems reasonable to expect that the Ox-LDL-induced macrophage proliferation might be linked to the development of atherosclerotic lesions. Thus, clarification of the molecular cascades of Ox-LDL-induced macrophage proliferation is expected to enhance our knowledge of the pathogenesis of atherosclerosis. Recently, we demonstrated that the activation of PKC leads to release into the culture medium of granulocyte/macrophage colony-stimulating factor (GM-CSF) which plays an important role in Ox-LDL-induced macrophage proliferation. In this review article, we mainly show the role of GM-CSF in the Ox-LDL-induced macrophage proliferation. Moreover, based on our recent findings, we summarize the Ox-LDL-induced signaling pathway for macrophage proliferation.
T Biwa; M Sakai; M Shichiri; S Horiuchi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  7     ISSN:  1340-3478     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2000  
Date Detail:
Created Date:  2001-06-26     Completed Date:  2001-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  IM    
Department of Metabolic Medicine, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Cell Division / drug effects,  physiology
Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology,  physiology*
Lipoproteins, LDL / metabolism*,  pharmacology
Macrophages / cytology*,  drug effects,  physiology
Protein Kinase C / metabolism
Recombinant Proteins / genetics,  pharmacology
Reg. No./Substance:
0/Lipoproteins, LDL; 0/Recombinant Proteins; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; EC Kinase C

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